NDUFA13
| Gene Symbol | NDUFA13 |
|---|---|
| Entrez Gene | 51079 |
| Alt Symbol | B16.6, CDA016, CGI-39, GRIM-19, GRIM19 |
| Species | Human |
| Gene Type | protein-coding |
| Description | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 |
| Other Description | CI-B16.6|NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13|NADH-ubiquinone oxidoreductase B16.6 subunit|cell death regulatory protein GRIM-19|cell death-regulatory protein GRIM19|complex I B16.6 subunit|complex I-B16.6|gene associated with retinoic and IFN-induced mortality 19 protein|gene associated with retinoic and interferon-induced mortality 19 protein |
| Swissprots | Q6PKI0 Q9Y327 Q9H2L3 Q9P0J0 K7EK58 B4DF76 |
| Accessions | EAW84826 Q9P0J0 AF261134 AAG44670 AF286697 AAG28167 AK293859 BAG57254 BC000589 AAH00589 BC009189 AAH09189 BG705222 BG724220 BM839920 BP230223 DB450544 NM_015965 NP_057049 |
| Function | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes. {ECO:0000269|PubMed:12628925, ECO:0000269|PubMed:12867595, ECO:0000269|PubMed:15753091}. |
| Subcellular Location | Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. Nucleus. Note=May be translocated into the nucleus upon IFN/RA treatment. |
| Tissue Specificity | Widely expressed, with highest expression in heart, skeletal muscle, liver, kidney and placenta. In intestinal mucosa, down-regulated in areas involved in Crohn disease and ulcerative colitis. {ECO:0000269|PubMed:10924506}. |
| Top Pathways | Alzheimer's disease, Huntington's disease, Non-alcoholic fatty liver disease (NAFLD), Oxidative phosphorylation |
Human GRIM19 full length protein - ab162405 from Abcam
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NDUFA13 / GRIM19 Antibody Blocking Peptide - LS-E3082 from LifeSpan Bioscience
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Recombinant Human GRIM19 Protein - H00051079-P01 from Novus Biologicals
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NDUFA13-Antibody-N-term-Blocking-Peptide - BP14220a from Abgent, a WuXi AppTec company
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GRIM19 blocking peptide - GTX89416-PEP from GeneTex
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NDUFA13 - H00051079-P01-10 from Acris Antibodies
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NDUFA13 - H00051079-P01-25 from Acris Antibodies
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GRIM19 fusion protein - ag1435 from Proteintech Group
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GRIM19 Recombinant Protein Antigen - NBP1-90050PEP from Novus Biologicals
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GRIM19 fusion protein - Ag20855 from Proteintech Group
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NDUFA13 Peptide, Human - M34GP10231H from Creative Peptides
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NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (NDUFA13), Recombinant Protein - MBS7023207 from MyBioSource
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NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (NDUFA13), Recombinant Protein - MBS7023208 from MyBioSource
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NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (NDUFA13), Recombinant Protein - MBS7023211 from MyBioSource
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NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (NDUFA13), Recombinant Protein - MBS7023212 from MyBioSource
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Recombinant Human NDUFA13 Protein, HIS-tagged - NDUFA13-058H from Creative Biomart
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Recombinant Human NDUFA13 Protein, GST-tagged - NDUFA13-5342H from Creative Biomart
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