NDUFA13
| Gene Symbol | NDUFA13 |
|---|---|
| Entrez Gene | 51079 |
| Alt Symbol | B16.6, CDA016, CGI-39, GRIM-19, GRIM19 |
| Species | Human |
| Gene Type | protein-coding |
| Description | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 |
| Other Description | CI-B16.6|NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13|NADH-ubiquinone oxidoreductase B16.6 subunit|cell death regulatory protein GRIM-19|cell death-regulatory protein GRIM19|complex I B16.6 subunit|complex I-B16.6|gene associated with retinoic and IFN-induced mortality 19 protein|gene associated with retinoic and interferon-induced mortality 19 protein |
| Swissprots | Q6PKI0 Q9Y327 Q9H2L3 Q9P0J0 K7EK58 B4DF76 |
| Accessions | EAW84826 Q9P0J0 AF261134 AAG44670 AF286697 AAG28167 AK293859 BAG57254 BC000589 AAH00589 BC009189 AAH09189 BG705222 BG724220 BM839920 BP230223 DB450544 NM_015965 NP_057049 |
| Function | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes. {ECO:0000269|PubMed:12628925, ECO:0000269|PubMed:12867595, ECO:0000269|PubMed:15753091}. |
| Subcellular Location | Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. Nucleus. Note=May be translocated into the nucleus upon IFN/RA treatment. |
| Tissue Specificity | Widely expressed, with highest expression in heart, skeletal muscle, liver, kidney and placenta. In intestinal mucosa, down-regulated in areas involved in Crohn disease and ulcerative colitis. {ECO:0000269|PubMed:10924506}. |
| Top Pathways | Alzheimer's disease, Huntington's disease, Non-alcoholic fatty liver disease (NAFLD), Oxidative phosphorylation |
Grim19 CRISPR/Cas9 KO Plasmid (h) - sc-403264 from Santa Cruz Biotechnology
|
||||||||
Grim19 HDR Plasmid (h) - sc-403264-HDR from Santa Cruz Biotechnology
|
||||||||
Grim19 Double Nickase Plasmid (h) - sc-403264-NIC from Santa Cruz Biotechnology
|
||||||||
Grim19 Double Nickase Plasmid (h2) - sc-403264-NIC-2 from Santa Cruz Biotechnology
|
||||||||
Grim19 CRISPR Activation Plasmid (h) - sc-403264-ACT from Santa Cruz Biotechnology
|
||||||||
Grim19 CRISPR Activation Plasmid (h2) - sc-403264-ACT-2 from Santa Cruz Biotechnology
|
||||||||
Grim19 Lentiviral Activation Particles (h) - sc-403264-LAC from Santa Cruz Biotechnology
|
||||||||
Grim19 Lentiviral Activation Particles (h2) - sc-403264-LAC-2 from Santa Cruz Biotechnology
|
||||||||
Grim19 siRNA (h) - sc-60765 from Santa Cruz Biotechnology
|
||||||||
Grim19 shRNA Plasmid (h) - sc-60765-SH from Santa Cruz Biotechnology
|
||||||||
Grim19 shRNA (h) Lentiviral Particles - sc-60765-V from Santa Cruz Biotechnology
|
||||||||
GRIM19 RNAi - H00051079-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU028201 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN15138 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15138 from Sigma-Aldrich
|
||||||||
NDUFA13 siRNA (Human) - CRH9502 from Cohesion Biosciences
|
||||||||
NDUFA13 shRNA Plasmid (Human) - CHH9502 from Cohesion Biosciences
|
||||||||
NDUFA13 miRNA 3'UTR clone - MiUTR3H-10607 from Creative biogene
|
||||||||