SP1

Gene Symbol	SP1
Entrez Gene	6667
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	Sp1 transcription factor
Other Description	specificity protein 1|transcription factor Sp1
Swissprots	Q9NY21 Q9H3Q5 E4Z9M7 Q9NR51 P08047 Q86TN8 Q9NYE7 G5E9M8
Accessions	AAF75063 AAF78780 BAB13476 CAP12210 CCQ43200 EAW96698 EAW96699 EAW96700 P08047 AB209678 BAD92915 AF252284 AAF67726 AF255682 AAF78781 AI282745 AI561005 AJ272134 CAB75345 AK311995 BAG34933 AL442093 AW028976 BC012008 BC043224 AAH43224 BC062539 AAH62539 BC078158 BF434304 BF436290 BF671559 BM463205 BQ072120 BQ431320 BQ774060 CD104746 FJ949572 ACR22508 FN908228 CBM42955 J03133 AAA61154 XM_011538696 XP_011536998 NM_001251825 NP_001238754 NM_003109 NP_003100 NM_138473 NP_612482
Function	Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/
Subcellular Location	Nucleus. Cytoplasm. Note=Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location.
Tissue Specificity	Up-regulated in adenocarcinomas of the stomach (at protein level). Isoform 3 is ubiquitously expressed at low levels. {ECO:0000269|PubMed:21798247}.
Top Pathways	TGF-beta signaling pathway, Huntington's disease, Estrogen signaling pathway, Choline metabolism in cancer, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat SP1 ELISA Kit (Cell-Based ELISA) - LS-F3312 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate

Mouse/Human/Rat SP1 ELISA Kit (DNA-Binding ELISA) - LS-F798 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate

Mouse/Human/Rat Phospho-SP1 (Thr453) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1223 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate

Mouse/Human/Rat Phospho-SP1 (Thr739) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1620 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate

Rabbit anti-Sp1 Antibody, Affinity Purified - PLA0044 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Goat anti-Sp1 Antibody, Affinity Purified - PLA0307 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Transcription factor Sp1 (SP1), Human, ELISA Kit - CSB-EL022438HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

SP1 Colorimetric Cell-Based ELISA - CB6157 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

SP1 (Phospho-Thr453) Colorimetric Cell-Based ELISA Kit - CBP1217 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

SP1 (Phospho-Thr739) Colorimetric Cell-Based ELISA Kit - CBP1675 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

SP1 TFact™ DNA-Binding ELISA - TFE-7141 from Assay Biotechnology Category ELISA Kit Prices $495.00, $990.00, $1,485.00 Sizes 1 kit, 2 kits, 3 kits

Sp1 transcription factor, ELISA Kit - MBS936215 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human SP1 is typically less than 6.25 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 25 pg/ml -1600 pg/ml.

Human Transcription factor Sp1(SP1) ELISA kit - CSB-EL022438HU from Cusabio Category ELISA Kit Sensitivity 6.25 pg/ml Range 25 pg/ml-1600 pg/ml

Human SP1 ELISA Kit (Custom ELISA) - LS-F17821 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range To be determined

Rat SP1 ELISA Kit (Custom ELISA) - LS-F17822 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range To be determined

Mouse SP1 ELISA Kit (Custom ELISA) - LS-F17823 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range To be determined

ELISA Kit for Specificity Protein 1 (Sp1) - SEM264Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.054ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Specificity Protein 1 (Sp1) - SEM264Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.054ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Transcription factor Sp1 (SP1) ELISA Kit - EKC35835 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 6.25 pg/ml Range 25 pg/ml-1600 pg/ml

SP1 ELISA Kit (Human) (OKCD00618) - OKCD00618 from Aviva Systems Biology Category ELISA Kit Prices $585.00 Sizes 96 wells Sensitivity < 0.054 ng/mL Range 0.156-10 ng/mL

Transcription factor Sp1 (SP1), ELISA Kit - MBS2610486 from MyBioSource Category ELISA Kit Prices $300.00, $475.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transcription factor Sp1, ELISA Kit - MBS2606824 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transcription factor Sp1, ELISA Kit - MBS2604047 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transcription factor Sp1 (SP1), ELISA Kit - MBS286229 from MyBioSource Category ELISA Kit Prices $405.00, $660.00, $2,825.00, $5,405.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 15.6 pg/mL - 1000 pg/mL

Transcription factor Sp1 , ELISA Kit - MBS2604197 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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