| Gene Symbol |
SP1
|
| Entrez Gene |
6667
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Sp1 transcription factor
|
| Other Description |
specificity protein 1|transcription factor Sp1
|
| Swissprots |
Q9NY21 Q9H3Q5 E4Z9M7 Q9NR51 P08047 Q86TN8 Q9NYE7 G5E9M8
|
| Accessions |
AAF75063 AAF78780 BAB13476 CAP12210 CCQ43200 EAW96698 EAW96699 EAW96700 P08047 AB209678 BAD92915 AF252284 AAF67726 AF255682 AAF78781 AI282745 AI561005 AJ272134 CAB75345 AK311995 BAG34933 AL442093 AW028976 BC012008 BC043224 AAH43224 BC062539 AAH62539 BC078158 BF434304 BF436290 BF671559 BM463205 BQ072120 BQ431320 BQ774060 CD104746 FJ949572 ACR22508 FN908228 CBM42955 J03133 AAA61154 XM_011538696 XP_011536998 NM_001251825 NP_001238754 NM_003109 NP_003100 NM_138473 NP_612482
|
| Function |
Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location.
|
| Tissue Specificity |
Up-regulated in adenocarcinomas of the stomach (at protein level). Isoform 3 is ubiquitously expressed at low levels. {ECO:0000269|PubMed:21798247}.
|
| Top Pathways |
TGF-beta signaling pathway, Huntington's disease, Estrogen signaling pathway, Choline metabolism in cancer, Transcriptional misregulation in cancer
|