SP1

Gene Symbol	SP1
Entrez Gene	6667
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	Sp1 transcription factor
Other Description	specificity protein 1|transcription factor Sp1
Swissprots	Q9NY21 Q9H3Q5 E4Z9M7 Q9NR51 P08047 Q86TN8 Q9NYE7 G5E9M8
Accessions	AAF75063 AAF78780 BAB13476 CAP12210 CCQ43200 EAW96698 EAW96699 EAW96700 P08047 AB209678 BAD92915 AF252284 AAF67726 AF255682 AAF78781 AI282745 AI561005 AJ272134 CAB75345 AK311995 BAG34933 AL442093 AW028976 BC012008 BC043224 AAH43224 BC062539 AAH62539 BC078158 BF434304 BF436290 BF671559 BM463205 BQ072120 BQ431320 BQ774060 CD104746 FJ949572 ACR22508 FN908228 CBM42955 J03133 AAA61154 XM_011538696 XP_011536998 NM_001251825 NP_001238754 NM_003109 NP_003100 NM_138473 NP_612482
Function	Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/
Subcellular Location	Nucleus. Cytoplasm. Note=Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location.
Tissue Specificity	Up-regulated in adenocarcinomas of the stomach (at protein level). Isoform 3 is ubiquitously expressed at low levels. {ECO:0000269|PubMed:21798247}.
Top Pathways	TGF-beta signaling pathway, Huntington's disease, Estrogen signaling pathway, Choline metabolism in cancer, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® SP1 siRNA II - 12106 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® SP1 siRNA I - 12104 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

Sp1 CRISPR/Cas9 KO Plasmid (h) - sc-400166 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Sp1 HDR Plasmid (h) - sc-400166-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Sp1 Double Nickase Plasmid (h) - sc-400166-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Sp1 Double Nickase Plasmid (h2) - sc-400166-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Sp1 CRISPR Activation Plasmid (h) - sc-400166-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Sp1 CRISPR Activation Plasmid (h2) - sc-400166-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Sp1 Lentiviral Activation Particles (h) - sc-400166-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Sp1 Lentiviral Activation Particles (h2) - sc-400166-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Sp1 siRNA (h) - sc-29487 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Sp1 shRNA Plasmid (h) - sc-29487-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Sp1 shRNA (h) Lentiviral Particles - sc-29487-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Sp1 siRNA (h2) - sc-44221 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Sp1 shRNA Plasmid (h2) - sc-44221-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Sp1 shRNA (h2) Lentiviral Particles - sc-44221-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU018231 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1517 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1517 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

SP1 siRNA (Human) - CRH4546 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SP1 RNAi - H00006667-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

SP1 - MBS8229745 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human SP1 (NM_138473.2) - SHH415516 from Creative biogene Category siRNA Species Reactivities Human

Human SP1 siRNA - orb265048 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SP1 shRNA Plasmid (Human) - CHH4546 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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