BLNK

Gene Symbol	BLNK
Entrez Gene	29760
Alt Symbol	AGM4, BASH, BLNK-S, LY57, SLP-65, SLP65, bca
Species	Human
Gene Type	protein-coding
Description	B-cell linker
Other Description	B cell adaptor containing SH2 domain|B cell linker protein|B-cell activation|B-cell adapter containing a SH2 domain protein|B-cell adapter containing a Src homology 2 domain protein|B-cell linker protein|Src homology 2 domain-containing leukocyte protein of 65 kDa|Src homology [SH2] domain-containing leukocyte protein of 65 kD|cytoplasmic adapter protein
Swissprots	O75498 Q2MD49 O75499 Q8WV28
Accessions	AAF20382 AAF20383 CAJ55341 EAW49980 EAW49981 Q8WV28 AF068180 AAC39936 AF068181 AAC39937 AI307343 AK027779 BAG51377 AK225546 AM180327 CAJ55321 AM180328 CAJ55322 AM180329 CAJ55323 AM180330 CAJ55324 AM180331 CAJ55325 AM180332 CAJ55326 AM180333 CAJ55327 AM180334 CAJ55328 AM180335 CAJ55329 AM180336 CAJ55330 AM180337 CAJ55331 AM180338 CAJ55332 AM180339 CAJ55333 AM180340 CAJ55334 AM180341 CAJ55335 AM180342 CAJ55336 AM180343 CAJ55337 AM180344 CAJ55338 AM180345 CAJ55339 AM180346 CAJ55340 BC018906 AAH18906 BC110298 BF975580 BM820310 BU597768 DA045252 XM_011539728 XP_011538030 NM_001114094 NP_001107566 NM_001258440 NP_001245369 NM_001258441 NP_001245370 NM_001258442 NP_001245371 NM_013314 NP_037446 NR_047680 NR_047681 NR_047682 NR_047683
Function	Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR- mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis. {ECO:0000269|PubMed:10583958, ECO:0000269|PubMed:15270728, ECO:0000269|PubMed:16912232, ECO:0000269|PubMed:9697839}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:9697839}. Cell membrane {ECO:0000269|PubMed:9697839}. Note=BCR activation results in the translocation to membrane fraction.
Tissue Specificity	Expressed in B-cell lineage and fibroblast cell lines (at protein level). Highest levels of expression in the spleen, with lower levels in the liver, kidney, pancreas, small intestines and colon.
Top Pathways	B cell receptor signaling pathway, Primary immunodeficiency, Osteoclast differentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Phospho-BLNK (Tyr96) Antibody - 3601 from Cell Signaling Technology Prices $109.00, $287.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

BLNK (D8R3G) Rabbit mAb - 12168 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D8R3G

BLNK Antibody - 3602 from Cell Signaling Technology Host Rabbit Clonality Polyclonal

BLNK Antibody - 3587 from Cell Signaling Technology Host Rabbit Clonality Polyclonal

BLNK (H-80) - sc-15345 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

BLNK (C-19) - sc-8382 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

BLNK (2B11) - sc-8003 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Anti-BLNK (phospho Y84) antibody - ab79320 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-BLNK (phospho Y84) antibody [EP2202(2)] - ab174837 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EP2202(2)

Anti-BLNK (phospho Y96) antibody - ab73204 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-BLNK (phospho Y96) antibody - ab195822 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-BLNK antibody - ab73706 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-BLNK antibody - ab97407 from Abcam Prices $370.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-BLNK antibody - ab2230 from Abcam Prices $370.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-BLNK antibody [Y491] - ab32418 from Abcam Prices $313.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone Y491

Anti-BLNK Antibody (aa171-356) - LS-C4117 from LifeSpan Bioscience Prices $465.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-BLNK Antibody (phospho-Tyr96) - LS-C4118 from LifeSpan Bioscience Prices $425.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-BLNK Antibody (aa171-356) - LS-C43087 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-BLNK Antibody (aa171-356) - LS-C46080 from LifeSpan Bioscience Prices $290.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-BLNK Antibody (aa171-356) - LS-C74680 from LifeSpan Bioscience Prices $530.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-BLNK Antibody (aa444-456) - LS-C20135 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-BLNK Antibody (C-Terminus, clone Y491) - LS-C49570 from LifeSpan Bioscience Prices $395.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone Y491

Anti-BLNK Antibody (aa171-356) - LS-C202774 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-BLNK Antibody (Internal, AP) - LS-C243808 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BLNK Antibody (C-Terminus) - LS-C107723 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

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