| Gene Symbol |
BLNK
|
| Entrez Gene |
29760
|
| Alt Symbol |
AGM4, BASH, BLNK-S, LY57, SLP-65, SLP65, bca
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
B-cell linker
|
| Other Description |
B cell adaptor containing SH2 domain|B cell linker protein|B-cell activation|B-cell adapter containing a SH2 domain protein|B-cell adapter containing a Src homology 2 domain protein|B-cell linker protein|Src homology 2 domain-containing leukocyte protein of 65 kDa|Src homology [SH2] domain-containing leukocyte protein of 65 kD|cytoplasmic adapter protein
|
| Swissprots |
O75498 Q2MD49 O75499 Q8WV28
|
| Accessions |
AAF20382 AAF20383 CAJ55341 EAW49980 EAW49981 Q8WV28 AF068180 AAC39936 AF068181 AAC39937 AI307343 AK027779 BAG51377 AK225546 AM180327 CAJ55321 AM180328 CAJ55322 AM180329 CAJ55323 AM180330 CAJ55324 AM180331 CAJ55325 AM180332 CAJ55326 AM180333 CAJ55327 AM180334 CAJ55328 AM180335 CAJ55329 AM180336 CAJ55330 AM180337 CAJ55331 AM180338 CAJ55332 AM180339 CAJ55333 AM180340 CAJ55334 AM180341 CAJ55335 AM180342 CAJ55336 AM180343 CAJ55337 AM180344 CAJ55338 AM180345 CAJ55339 AM180346 CAJ55340 BC018906 AAH18906 BC110298 BF975580 BM820310 BU597768 DA045252 XM_011539728 XP_011538030 NM_001114094 NP_001107566 NM_001258440 NP_001245369 NM_001258441 NP_001245370 NM_001258442 NP_001245371 NM_013314 NP_037446 NR_047680 NR_047681 NR_047682 NR_047683
|
| Function |
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR- mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis. {ECO:0000269|PubMed:10583958, ECO:0000269|PubMed:15270728, ECO:0000269|PubMed:16912232, ECO:0000269|PubMed:9697839}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:9697839}. Cell membrane {ECO:0000269|PubMed:9697839}. Note=BCR activation results in the translocation to membrane fraction.
|
| Tissue Specificity |
Expressed in B-cell lineage and fibroblast cell lines (at protein level). Highest levels of expression in the spleen, with lower levels in the liver, kidney, pancreas, small intestines and colon.
|
| Top Pathways |
B cell receptor signaling pathway, Primary immunodeficiency, Osteoclast differentiation
|