BLNK

Gene Symbol	BLNK
Entrez Gene	29760
Alt Symbol	AGM4, BASH, BLNK-S, LY57, SLP-65, SLP65, bca
Species	Human
Gene Type	protein-coding
Description	B-cell linker
Other Description	B cell adaptor containing SH2 domain|B cell linker protein|B-cell activation|B-cell adapter containing a SH2 domain protein|B-cell adapter containing a Src homology 2 domain protein|B-cell linker protein|Src homology 2 domain-containing leukocyte protein of 65 kDa|Src homology [SH2] domain-containing leukocyte protein of 65 kD|cytoplasmic adapter protein
Swissprots	O75498 Q2MD49 O75499 Q8WV28
Accessions	AAF20382 AAF20383 CAJ55341 EAW49980 EAW49981 Q8WV28 AF068180 AAC39936 AF068181 AAC39937 AI307343 AK027779 BAG51377 AK225546 AM180327 CAJ55321 AM180328 CAJ55322 AM180329 CAJ55323 AM180330 CAJ55324 AM180331 CAJ55325 AM180332 CAJ55326 AM180333 CAJ55327 AM180334 CAJ55328 AM180335 CAJ55329 AM180336 CAJ55330 AM180337 CAJ55331 AM180338 CAJ55332 AM180339 CAJ55333 AM180340 CAJ55334 AM180341 CAJ55335 AM180342 CAJ55336 AM180343 CAJ55337 AM180344 CAJ55338 AM180345 CAJ55339 AM180346 CAJ55340 BC018906 AAH18906 BC110298 BF975580 BM820310 BU597768 DA045252 XM_011539728 XP_011538030 NM_001114094 NP_001107566 NM_001258440 NP_001245369 NM_001258441 NP_001245370 NM_001258442 NP_001245371 NM_013314 NP_037446 NR_047680 NR_047681 NR_047682 NR_047683
Function	Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR- mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis. {ECO:0000269|PubMed:10583958, ECO:0000269|PubMed:15270728, ECO:0000269|PubMed:16912232, ECO:0000269|PubMed:9697839}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:9697839}. Cell membrane {ECO:0000269|PubMed:9697839}. Note=BCR activation results in the translocation to membrane fraction.
Tissue Specificity	Expressed in B-cell lineage and fibroblast cell lines (at protein level). Highest levels of expression in the spleen, with lower levels in the liver, kidney, pancreas, small intestines and colon.
Top Pathways	B cell receptor signaling pathway, Primary immunodeficiency, Osteoclast differentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human BLNK full length protein - ab104120 from Abcam Category Protein Prices $235.00, $866.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Human BLNK peptide - ab22871 from Abcam Category Peptide Prices $176.00 Sizes 100 µg Species Human

BLNK Antibody Blocking Peptide - LS-E2422 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BLNK Antibody Blocking Peptide - LS-E25225 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BLNK Antibody Blocking Peptide - LS-E8237 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BLNK Partial Recombinant Protein - H00029760-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

BLNK Recombinant Protein - H00029760-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human BLNK Protein - NBP1-50993 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

BLNK-Antibody-N-term-Blocking-peptide - BP13433a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BLNK-Antibody-Center-Blocking-Peptide - BP6502c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BLNK blocking peptide - GTX89949-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Bovine

BLNK Protein (OPPA00063) - OPPA00063 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source Escherichia Coli.

Human BLNK protein - orb167985 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli

Human BLNK protein - orb49213 from Biorbyt Category Protein Prices $408.00, $595.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

BLNK Blocking Peptide - 33R-7788 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

BLNK protein (His tag) - 80R-1673 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

BLNK Blocking Peptide - abx063836 from Abbexa Category Peptide Species Human

Human B-Cell Linker Protein Protein - abx065515 from Abbexa Category Protein Source E.coli Species Human

BLNK Peptide - AC21-0049-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

B-cell linker protein / BLNK (1-456, His-tag) - AR09855PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

B-cell linker protein / BLNK (1-456, His-tag) - AR09855PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

B-cell linker protein / BLNK - H00029760-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

B-cell linker protein / BLNK - H00029760-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

B-Cell Linker, Human Recombinant - 228-12841-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant B-Cell Linker Human - 228-12841-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

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