| Gene Symbol |
CDCA7L
|
| Entrez Gene |
55536
|
| Alt Symbol |
JPO2, R1, RAM2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cell division cycle associated 7-like
|
| Other Description |
cell division cycle-associated 7-like protein|transcription factor RAM2
|
| Swissprots |
Q6PIL4 Q8IXN5 B4DUT3 Q9NPV2 A6NF50 Q96C70 A4D141 B3KTR5 Q86YT0 Q9H9A2 Q96GN5 C9K0Y1
|
| Accessions |
AAS02007 EAL24271 EAW93740 EAW93741 EAW93742 EAW93743 EAW93744 Q96GN5 AA922229 AK022955 BAB14330 AK095965 BAG53177 AK292490 BAF85179 AK300781 BAG62445 AL359619 CAB94887 AL576822 AY161168 AAO17570 AY161169 AAO17571 BC009352 AAH09352 BC014630 AAH14630 BC025242 AAH25242 BC032576 AAH32576 BC039823 AAH39823 BI493265 BU753973 BX112809 BX422040 DA041070 DC331792 HQ448527 ADQ33006 NM_001127370 NP_001120842 NM_001127371 NP_001120843 NM_018719 NP_061189
|
| Function |
Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. {ECO:0000269|PubMed:15654081, ECO:0000269|PubMed:15994933, ECO:0000269|PubMed:16829576}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.
|
| Tissue Specificity |
Ubiquitous. Overexpressed in medulloblastoma. {ECO:0000269|PubMed:15654081, ECO:0000269|PubMed:15994933}.
|
![Western Blot: CDCA7L Overexpression Lysate (Adult Normal) [NBL1-09021] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CDCA7L.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/11712_CDCA7L%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-09021-img0002.jpg)
