| Gene Symbol |
TARBP1
|
| Entrez Gene |
6894
|
| Alt Symbol |
TRM3, TRP-185, TRP185
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TAR (HIV-1) RNA binding protein 1
|
| Other Description |
TAR (HIV) RNA binding protein 1|TAR (HIV) RNA-binding protein 1|TAR RNA loop binding protein|TAR RNA-binding protein 1|TAR RNA-binding protein of 185 kDa|probable methyltransferase TARBP1|tRNA methyltransferase 3 homolog
|
| Swissprots |
Q9H581 Q13395
|
| Accessions |
EAW69993 Q13395 AA714641 AK055044 BC016023 BC156249 AAI56250 U38847 AAC50379 XM_005273234 XP_005273291 XM_006711812 XP_006711875 XM_011544263 XP_011542565 XM_011544264 XP_011542566 XM_011544265 XP_011542567 XR_949155 XR_949156 XR_949157 XR_949158 NM_005646 NP_005637
|
| Function |
Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. May act by methylating HIV-1 TAR RNA. {ECO:0000269|PubMed:7638159, ECO:0000269|PubMed:8626763, ECO:0000269|PubMed:8846792}.
|