| Gene Symbol |
Bcl2l11
|
| Entrez Gene |
12125
|
| Alt Symbol |
1500006F24Rik, Bim, Bod, bcl2-L-11
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
BCL2-like 11 (apoptosis facilitator)
|
| Other Description |
Bcl2 interacting mediator of cell death|bcl-2-like protein 11|bcl2-interacting mediator of cell death
|
| Swissprots |
O54920 O54919 O54918 A2ALQ6
|
| Accessions |
EDL28212 EDL28213 EDL28214 O54918 AA275665 AA881651 AF032459 AAC40029 AF032460 AAC40030 AF032461 AAC40031 AK011490 AK031285 AK037885 AK050192 AK082613 BAC38548 AK150464 BAE29581 AK152472 BAE31246 AK153542 BAE32079 AK162975 BAE37144 AK177547 BC019556 AAH19556 BC058175 AAH58175 BE136124 CA321725 CB521709 XM_006498614 XP_006498677 XM_006498615 XP_006498678 XM_006498616 XP_006498679 XM_006498617 XP_006498680 NM_001284410 NP_001271339 NM_001291016 NP_001277945 NM_009754 NP_033884 NM_207680 NP_997563 NM_207681 NP_997564
|
| Function |
Induces apoptosis and anoikis. The isoforms vary in cytotoxicity with isoform BimS being the most potent and isoform BimEL being the least potent. {ECO:0000269|PubMed:9430630}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:9430630}; Peripheral membrane protein {ECO:0000269|PubMed:9430630}. Mitochondrion {ECO:0000250}. Note=Associated with intracytoplasmic membranes.
|
| Tissue Specificity |
Expressed in a number of B- and T-lymphoid cell lines. {ECO:0000269|PubMed:9430630}.
|
| Top Pathways |
PI3K-Akt signaling pathway, MicroRNAs in cancer, Non-alcoholic fatty liver disease (NAFLD)
|