ITPK1

Gene Symbol	ITPK1
Entrez Gene	3705
Alt Symbol	ITRPK1
Species	Human
Gene Type	protein-coding
Description	inositol-tetrakisphosphate 1-kinase
Other Description	inositol 1,3,4-triphosphate 5/6 kinase|inositol 1,3,4-trisphosphate 5/6 kinase|inositol 1,3,4-trisphosphate 5/6-kinase|inositol-triphosphate 5/6-kinase|ins(1,3,4)P(3) 5/6-kinase
Swissprots	Q9H2E7 Q13572 Q9BTL6
Accessions	EAW81507 EAW81508 EAW81509 EAW81510 EAW81511 EAW81512 EAW81513 Q13572 AA770154 AF279372 AAG44835 AK293515 BAG56998 AY129028 AAM98771 BC003622 AAH03622 BC007428 AAH07428 BC018192 AAH18192 BC037305 AAH37305 BQ434653 BX420122 CB997740 DQ891434 ABM82360 DQ894609 ABM85535 U51336 AAC50483 NM_001142593 NP_001136065 NM_001142594 NP_001136066 NM_014216 NP_055031
Function	Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain. {ECO:0000269|PubMed:119
Tissue Specificity	Expressed in brain > heart > skeletal muscle = kidney = pancreas = liver = placenta > lung. In brain, it is expressed in cerebellum, cerebral cortex, medulla, spinal cord, occipital lobe, frontal lobe, temporal lobe and putamen. {ECO:0000269|PubMed:8662638}.
Top Pathways	Inositol phosphate metabolism, Phosphatidylinositol signaling system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ITPK1 full length protein - ab130021 from Abcam Category Protein Source E. coli Species Human

ITPK1 Antibody Blocking Peptide - LS-E6270 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ITPK1 Antibody Blocking Peptide - LS-E19842 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ITPK1 Antibody Blocking Peptide - LS-E19843 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ITPK1 Recombinant Protein - H00003705-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human ITPK1 Protein - NBP1-98867 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 100 µg, 500 µg Source E. coli Species Human

ITPK1-Antibody-N-term-Blocking-Peptide - BP18953a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human ITPK1 protein - orb168680 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 5 μg, 20 μg Source E.coli Species Human

ITPK1 Blocking Peptide - 33R-6637 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ITPK1 Blocking Peptide - 33R-5984 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ITPK1 protein (His tag) - 80R-2398 from Fitzgerald Category Protein Prices $365.00 Sizes 100 µg Source E.coli

ITPK1 (1-414, His-tag) - AR50479PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 500 µg Source E. coli Species Human

ITPK1 (1-414, His-tag) - AR50479PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 100 µg Source E. coli Species Human

ITPK1 - H00003705-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ITPK1 - H00003705-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ITPK1, 1-414aa Human, His tag, E.coli - 01-P1655 from ARP American Research Products Category Protein Prices $189.00, $449.00, $1,089.00 Sizes 20 µg, 50 µg, 500 µg Species Human

ITPK1 fusion protein - ag0834 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

ITPK1 Human - PKPS-047 from NeoScientific Category Protein Prices $65.00, $169.00, $4,680.00 Sizes 5 µg, 20 µg, 1 mg Source E.coli. Species Human

Recombinant Human Inositol-Tetrakisphosphate 1-Kinase Enzyme - BP002748-PKA-040 from Syd Labs Category Protein Prices $160.00, $3,600.00 Sizes 20 µg, 1 mg Source E. coli-derived. Species Human

Recombinant Human Inositol-Tetrakisphosphate 1-kinase, His-tagged - ITPK1-1351H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Inositol-tetrakisphosphate 1-kinase(ITPK1) - CSB-YP896449EKM CSB-EP896449EKM CSB-BP896449EKM CSB-MP896449EKM from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Entamoeba histolytica

Recombinant Human Inositol-tetrakisphosphate 1-kinase(ITPK1) - CSB-YP613412HU CSB-EP613412HU CSB-BP613412HU CSB-MP613412HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ITPK1, 1-414aa, Human, His tag, E.coli - ATGP1655 from ATGen Category Protein Prices $105.00, $320.00, $960.00 Sizes 20 µg, 100 µg, 500 µg Species Human

ITPK1 Protein - abx163523 from Abbexa Category Protein Species Human, Mouse, Rat

Inositol-Tetrakisphosphate 1-Kinase Protein (Recombinant) - abx073589 from Abbexa Category Protein

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