| Gene Symbol | ITPK1 |
|---|---|
| Entrez Gene | 3705 |
| Alt Symbol | ITRPK1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | inositol-tetrakisphosphate 1-kinase |
| Other Description | inositol 1,3,4-triphosphate 5/6 kinase|inositol 1,3,4-trisphosphate 5/6 kinase|inositol 1,3,4-trisphosphate 5/6-kinase|inositol-triphosphate 5/6-kinase|ins(1,3,4)P(3) 5/6-kinase |
| Swissprots | Q9H2E7 Q13572 Q9BTL6 |
| Accessions | EAW81507 EAW81508 EAW81509 EAW81510 EAW81511 EAW81512 EAW81513 Q13572 AA770154 AF279372 AAG44835 AK293515 BAG56998 AY129028 AAM98771 BC003622 AAH03622 BC007428 AAH07428 BC018192 AAH18192 BC037305 AAH37305 BQ434653 BX420122 CB997740 DQ891434 ABM82360 DQ894609 ABM85535 U51336 AAC50483 NM_001142593 NP_001136065 NM_001142594 NP_001136066 NM_014216 NP_055031 |
| Function | Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain. {ECO:0000269|PubMed:119 |
| Tissue Specificity | Expressed in brain > heart > skeletal muscle = kidney = pancreas = liver = placenta > lung. In brain, it is expressed in cerebellum, cerebral cortex, medulla, spinal cord, occipital lobe, frontal lobe, temporal lobe and putamen. {ECO:0000269|PubMed:8662638}. |
| Top Pathways | Inositol phosphate metabolism, Phosphatidylinositol signaling system |
ITPK1 CRISPR/Cas9 KO Plasmid (h) - sc-409464 from Santa Cruz Biotechnology
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ITPK1 HDR Plasmid (h) - sc-409464-HDR from Santa Cruz Biotechnology
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ITPK1 Double Nickase Plasmid (h) - sc-409464-NIC from Santa Cruz Biotechnology
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ITPK1 Double Nickase Plasmid (h2) - sc-409464-NIC-2 from Santa Cruz Biotechnology
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ITPK1 CRISPR Activation Plasmid (h) - sc-409464-ACT from Santa Cruz Biotechnology
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ITPK1 CRISPR Activation Plasmid (h2) - sc-409464-ACT-2 from Santa Cruz Biotechnology
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ITPK1 Lentiviral Activation Particles (h) - sc-409464-LAC from Santa Cruz Biotechnology
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ITPK1 Lentiviral Activation Particles (h2) - sc-409464-LAC-2 from Santa Cruz Biotechnology
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ITPK1 siRNA (h) - sc-92365 from Santa Cruz Biotechnology
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ITPK1 shRNA Plasmid (h) - sc-92365-SH from Santa Cruz Biotechnology
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ITPK1 shRNA (h) Lentiviral Particles - sc-92365-V from Santa Cruz Biotechnology
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ITPK1 RNAi - H00003705-R01V from Novus Biologicals
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ITPK1 RNAi - H00003705-R02 from Novus Biologicals
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MISSION® esiRNA - EHU063191 from Sigma-Aldrich
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MISSION® esiRNA - EHU005931 from Sigma-Aldrich
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MISSION® siRNA - SIHK0991 from Sigma-Aldrich
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MISSION® siRNA - SIHK0993 from Sigma-Aldrich
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MISSION® siRNA - SIHK0992 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10833 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10833 from Sigma-Aldrich
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ITPK1 siRNA (Human) - CRH2493 from Cohesion Biosciences
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ITPK1, siRNA - MBS8216080 from MyBioSource
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shRNA set against Human ITPK1 (NM_014216.4) - SHH321625 from Creative biogene
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ITPK1 shRNA Plasmid (Human) - CHH2493 from Cohesion Biosciences
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ITPK1 miRNA 3'UTR clone - MiUTR3H-04447 from Creative biogene
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