ITPK1

Gene Symbol	ITPK1
Entrez Gene	3705
Alt Symbol	ITRPK1
Species	Human
Gene Type	protein-coding
Description	inositol-tetrakisphosphate 1-kinase
Other Description	inositol 1,3,4-triphosphate 5/6 kinase|inositol 1,3,4-trisphosphate 5/6 kinase|inositol 1,3,4-trisphosphate 5/6-kinase|inositol-triphosphate 5/6-kinase|ins(1,3,4)P(3) 5/6-kinase
Swissprots	Q9H2E7 Q13572 Q9BTL6
Accessions	EAW81507 EAW81508 EAW81509 EAW81510 EAW81511 EAW81512 EAW81513 Q13572 AA770154 AF279372 AAG44835 AK293515 BAG56998 AY129028 AAM98771 BC003622 AAH03622 BC007428 AAH07428 BC018192 AAH18192 BC037305 AAH37305 BQ434653 BX420122 CB997740 DQ891434 ABM82360 DQ894609 ABM85535 U51336 AAC50483 NM_001142593 NP_001136065 NM_001142594 NP_001136066 NM_014216 NP_055031
Function	Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain. {ECO:0000269|PubMed:119
Tissue Specificity	Expressed in brain > heart > skeletal muscle = kidney = pancreas = liver = placenta > lung. In brain, it is expressed in cerebellum, cerebral cortex, medulla, spinal cord, occipital lobe, frontal lobe, temporal lobe and putamen. {ECO:0000269|PubMed:8662638}.
Top Pathways	Inositol phosphate metabolism, Phosphatidylinositol signaling system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ITPK1 (N-13) - sc-164713 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

ITPK1 (E-15) - sc-164711 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-ITPK1 antibody - ab97447 from Abcam Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ITPK1 antibody - ab137004 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ITPK1 antibody - ab55372 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-ITPK1 antibody [EPR10631] - ab175222 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR10631

Anti-ITPK1 Antibody (aa28-54, AP) - LS-C215307 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ITPK1 Antibody (aa28-54, APC) - LS-C215308 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ITPK1 Antibody (aa28-54, Biotin) - LS-C215309 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ITPK1 Antibody (aa179-228) - LS-C107845 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-ITPK1 Antibody (aa28-54, Azide-free, HRP) - LS-C215311 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ITPK1 Antibody (aa28-54, PE) - LS-C215312 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ITPK1 Antibody (aa36-85) - LS-C81975 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-ITPK1 Antibody (aa28-54, FITC) - LS-C215310 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ITPK1 Antibody - LS-C308554 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-ITPK1 Antibody (aa52-101) - LS-C292109 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ITPK1 Antibody - LS-C137215 from LifeSpan Bioscience Prices $255.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ITPK1 Antibody - LS-C308555 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-ITPK1 Antibody - LS-C310803 from LifeSpan Bioscience Prices $475.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ITPK1 Antibody - LS-C310806 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ITPK1 Antibody (aa28-54) - LS-C322310 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ITPK1 Antibody (aa28-54) - LS-C159946 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-ITPK1 Antibody (aa171-414) - LS-C185926 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ITPK1 Antibody (aa81-130) IHC-plus™ - LS-B9944 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

ITPK1 Antibody - H00003705-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

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