AIFM1

Gene Symbol AIFM1
Entrez Gene 9131
Alt Symbol AIF, CMT2D, CMTX4, COWCK, COXPD6, NADMR, NAMSD, PDCD8
Species Human
Gene Type protein-coding
Description apoptosis-inducing factor, mitochondrion-associated, 1
Other Description Neuropathy, axonal motor-sensory, with deafness and mental retardation|apoptosis-inducing factor 1, mitochondrial|neuropathy, axonal, motor-sensory with deafness and mental retardation (Cowchock syndrome)|programmed cell death 8 (apoptosis-inducing factor)|striatal apoptosis-inducing factor
Swissprots Q1L6K6 D3DTE9 O95831 Q6I9X6 Q2QKE4 B1ALN1 B2RB08 Q9Y3I4 Q9Y3I3 Q1L6K4 Q5JUZ7 A4QPB4
Accessions CCQ43101 EAX11810 EAX11811 EAX11812 O95831 AF100928 AAD16436 AF131759 AAD20036 AK000775 AK314446 BAG37055 AL049703 CAB41267 AL049704 CAB41268 AY795556 AAV54053 AY795557 AAV54054 BC111065 AAI11066 BC139738 AAI39739 BM807180 CR457379 CAG33660 DA624842 DB119488 DQ016496 AAY84737 DQ016498 AAY84739 DQ016500 AAY84741 NM_001130846 NP_001124318 NM_001130847 NP_001124319 NM_004208 NP_004199 NM_145812 NP_665811 NM_145813 NP_665812
Function Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase- independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner. {ECO:0000269|PubMed:17094969, ECO:0000269|PubMed:19418225, ECO:0000269|PubMed:20362274, ECO:0000269|PubMed:23217327}.
Subcellular Location Isoform 5: Cytoplasm {ECO:0000269|PubMed:16365034}.
Tissue Specificity Detected in muscle and skin fibroblasts (at protein level). Isoform 5 is frequently down-regulated in human cancers. {ECO:0000269|PubMed:16365034, ECO:0000269|PubMed:23217327}.
Top Pathways Apoptosis

AIF (D39D2) XP ® Rabbit mAb - 5318 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D39D2
Western blot analysis of extracts from Jurkat, C2C12, and C6 cells using AIF (D39D2) XP ® Rabbit mAb.

AIF Antibody - 4642 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from human (Jurkat), mouse (NIH/3T3), and rat (NBT-II) cell lines, using AIF Antibody.

AIF (B-9) - sc-55519 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
AIF (B-9): sc-55519. Western blot analysis of AIF expression in HeLa (A), Jurkat (B) and CTLL-2 (C) whole cell lysates.

AIF (D-20) - sc-9416 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
AIF (D-20): sc-9416. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast tumor showing cytoplasmic staining.

AIF (E-1) - sc-13116 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
AIF (E-1): sc-13116. Western blot analysis of AIF expression in Jurkat whole cell lysate.

AIF (E-11) - sc-390619 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
AIF (E-11): sc-390619. Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing cytoplasmic localization.

AIF (N-19) - sc-9417 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
AIF (N-19): sc-9417. Western blot analysis of AIF expression in non-transfected 293T: sc-117752 (A), mouse AIF transfected 293T: sc-118296 (B) and CTLL-2 (C) whole cell lysates.

AIF (H-300) - sc-5586 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
AIF (H-300): sc-5586. Western blot analysis of AIF expression in AML-193 (A), CCRF-CEM (B), Hep G2 (C) and MOLT-4 (D) whole cell lysates.

Anti-AIFM1 / AIF / PDCD8 Antibody (aa596-613) - LS-C313335 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
AIFM1 / AIF antibody. IHC(P): Rat Cardiac Muscle Tissue.

Anti-AIFM1 / AIF / PDCD8 Antibody (aa100-150) - LS-C289500 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human AIF by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-AIF used at a dilution of 1:200 (1 ug/ml).

Anti-AIFM1 / AIF / PDCD8 Antibody (aa563-613) - LS-C289501 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human AIF by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-AIF used at a dilution of 1:1000 (1 ug/mg).

Anti-AIFM1 / AIF / PDCD8 Antibody (clone 4E7) - LS-C169395 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4E7
IHC of paraffin-embedded human cervical cancer tissues using AIF mouse monoclonal antibody with DAB staining.

Anti-AIFM1 / AIF / PDCD8 Antibody (N-Terminus) IHC-plus™ - LS-B3744 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-AIFM1 / AIF antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3744 concentration 5 ug/ml.

Anti-AIFM1 / AIF / PDCD8 Antibody - LS-C332175 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded rat lung using AIFM1 antibody at dilution of 1:200 (400x lens).

Anti-AIFM1 / AIF / PDCD8 Antibody (aa593-606) IHC-plus™ - LS-B3765 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-AIFM1 / AIF antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3765 concentration 5 ug/ml.

Anti-AIFM1 / AIF / PDCD8 Antibody (aa593-606) - LS-C20360 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-AIFM1 / AIF / PDCD8 Antibody - LS-C44950 from LifeSpan Bioscience

Prices $370.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-AIFM1 / AIF / PDCD8 Antibody (aa109-122) - LS-C26601 from LifeSpan Bioscience

Prices $360.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of anti-AIF (NT) antibody at 1 ug/ml on K562 cell lysate.

Anti-AIFM1 / AIF / PDCD8 Antibody (aa517-531) - LS-C26600 from LifeSpan Bioscience

Prices $360.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of anti-AIF (IN) antibody at 1 ug/ml on K562 cell lysate (A) and rat (B) and mouse (C) heart tissue lysates.

Anti-AIFM1 / AIF / PDCD8 Antibody (aa81-130) - LS-C40540 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
AIFM1 / AIF antibody LS-C40540 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

Anti-AIFM1 / AIF / PDCD8 Antibody - LS-C48245 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of AIFM1 / AIF antibody LS-C48245.

Anti-AIFM1 / AIF / PDCD8 Antibody (C-Terminus) - LS-C121360 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-AIFM1 / AIF / PDCD8 Antibody (C-Terminus, clone E20) - LS-C49360 from LifeSpan Bioscience

Prices $505.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone E20
IHC of paraffin-embedded human cervical carcinoma using anti-AIF antibody.

Anti-AIFM1 / AIF / PDCD8 Antibody (C-Terminus) - LS-C112280 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
AIFM1 / AIF antibody LS-C112280 Western blot of Jurkat Cell lysate. Antibody concentration 1 ug/ml.

Anti-AIFM1 / AIF / PDCD8 Antibody - LS-C137395 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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