AIFM1

Gene Symbol	AIFM1
Entrez Gene	9131
Alt Symbol	AIF, CMT2D, CMTX4, COWCK, COXPD6, NADMR, NAMSD, PDCD8
Species	Human
Gene Type	protein-coding
Description	apoptosis-inducing factor, mitochondrion-associated, 1
Other Description	Neuropathy, axonal motor-sensory, with deafness and mental retardation|apoptosis-inducing factor 1, mitochondrial|neuropathy, axonal, motor-sensory with deafness and mental retardation (Cowchock syndrome)|programmed cell death 8 (apoptosis-inducing factor)|striatal apoptosis-inducing factor
Swissprots	Q1L6K6 D3DTE9 O95831 Q6I9X6 Q2QKE4 B1ALN1 B2RB08 Q9Y3I4 Q9Y3I3 Q1L6K4 Q5JUZ7 A4QPB4
Accessions	CCQ43101 EAX11810 EAX11811 EAX11812 O95831 AF100928 AAD16436 AF131759 AAD20036 AK000775 AK314446 BAG37055 AL049703 CAB41267 AL049704 CAB41268 AY795556 AAV54053 AY795557 AAV54054 BC111065 AAI11066 BC139738 AAI39739 BM807180 CR457379 CAG33660 DA624842 DB119488 DQ016496 AAY84737 DQ016498 AAY84739 DQ016500 AAY84741 NM_001130846 NP_001124318 NM_001130847 NP_001124319 NM_004208 NP_004199 NM_145812 NP_665811 NM_145813 NP_665812
Function	Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase- independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner. {ECO:0000269|PubMed:17094969, ECO:0000269|PubMed:19418225, ECO:0000269|PubMed:20362274, ECO:0000269|PubMed:23217327}.
Subcellular Location	Isoform 5: Cytoplasm {ECO:0000269|PubMed:16365034}.
Tissue Specificity	Detected in muscle and skin fibroblasts (at protein level). Isoform 5 is frequently down-regulated in human cancers. {ECO:0000269|PubMed:16365034, ECO:0000269|PubMed:23217327}.
Top Pathways	Apoptosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human AIFM1 / AIF / PDCD8 ELISA Kit (Sandwich ELISA) - LS-F4315 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 6.1 pg/ml Range 15.63-1000 pg/ml

Rat AIFM1 / AIF / PDCD8 ELISA Kit (Sandwich ELISA) - LS-F4868 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.061 ng/ml Range 15.63-1000 pg/ml

Human AIF ELISA Kit - abx150599 from Abbexa Category ELISA Kit Sensitivity 0.064 ng/ml Range 0.156 ng/ml - 10 ng/ml

Acidic isoferitin (AIF), Human, ELISA kit - CSB-EQ027577HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Apoptosis Inducing Factor, AIF, Human, ELISA Kit - E-EL-H0479 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Apoptosis Inducing Factor (AIF), Human, ELISA Kit - SEB064Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 0.064ng/mL Range 0.156-10ng/mL

Apoptosis inducing factor, AIF, Human, ELISA Kit - CSB-E09006h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 156 pg/ml Range 625 pg/ml-40000 pg/ml

Apoptosis-inducing factor 1, mitochondrial, AIFM1, Human, ELISA Kit - E1064h from ARP American Research Products Category ELISA Kit Prices $476.00 Sizes 96 t Range 0.156-10 ng/mL

Apoptosis Inducing Factor, AIF, Mouse, ELISA Kit - E-EL-M0141 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 4.688 Range 7.813-500pg/mL

Apoptosis Inducing Factor, AIF, Rabbit, ELISA Kit - E-EL-RB1784 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Apoptosis Inducing Factor, AIF, Chicken, ELISA Kit - E-EL-Ch2226 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Apoptosis Inducing Factor, AIF, Porcine, ELISA Kit - E-EL-P1508 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Apoptosis Inducing Factor, AIF, Sheep, ELISA Kit - E-EL-S0288 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Apoptosis Inducing Factor, AIF, Monkey, ELISA Kit - E-EL-MK1776 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human AIF ELISA Kit - HA0535 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine AIF ELISA Kit - AA0535 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

AIF, ELISA Kit - MBS2506520 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156--10ng/mL

AIF, ELISA Kit - MBS2502968 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

AIF, ELISA Kit - MBS2504588 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 37.5pg/mL Range 62.5-4000pg/mL

AIF, ELISA Kit - MBS2508965 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

AIF, ELISA Kit - MBS2504129 from MyBioSource Category ELISA Kit Prices $490.00, $585.00, $2,475.00, $4,360.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.469ng/mL Range 0.781-50ng/mL

AIF, ELISA Kit - MBS2508739 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

AIF, ELISA Kit - MBS2503405 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 4.688pg/mL Range 7.813--500pg/mL

Human AIF(Apoptosis Inducing Factor) ELISA Kit - E-EL-H0479 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Human AIF (Apoptosis Inducing Factor) CLIA Kit - E-CL-H0391 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

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