AIFM1

Gene Symbol	AIFM1
Entrez Gene	9131
Alt Symbol	AIF, CMT2D, CMTX4, COWCK, COXPD6, NADMR, NAMSD, PDCD8
Species	Human
Gene Type	protein-coding
Description	apoptosis-inducing factor, mitochondrion-associated, 1
Other Description	Neuropathy, axonal motor-sensory, with deafness and mental retardation|apoptosis-inducing factor 1, mitochondrial|neuropathy, axonal, motor-sensory with deafness and mental retardation (Cowchock syndrome)|programmed cell death 8 (apoptosis-inducing factor)|striatal apoptosis-inducing factor
Swissprots	Q1L6K6 D3DTE9 O95831 Q6I9X6 Q2QKE4 B1ALN1 B2RB08 Q9Y3I4 Q9Y3I3 Q1L6K4 Q5JUZ7 A4QPB4
Accessions	CCQ43101 EAX11810 EAX11811 EAX11812 O95831 AF100928 AAD16436 AF131759 AAD20036 AK000775 AK314446 BAG37055 AL049703 CAB41267 AL049704 CAB41268 AY795556 AAV54053 AY795557 AAV54054 BC111065 AAI11066 BC139738 AAI39739 BM807180 CR457379 CAG33660 DA624842 DB119488 DQ016496 AAY84737 DQ016498 AAY84739 DQ016500 AAY84741 NM_001130846 NP_001124318 NM_001130847 NP_001124319 NM_004208 NP_004199 NM_145812 NP_665811 NM_145813 NP_665812
Function	Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase- independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner. {ECO:0000269|PubMed:17094969, ECO:0000269|PubMed:19418225, ECO:0000269|PubMed:20362274, ECO:0000269|PubMed:23217327}.
Subcellular Location	Isoform 5: Cytoplasm {ECO:0000269|PubMed:16365034}.
Tissue Specificity	Detected in muscle and skin fibroblasts (at protein level). Isoform 5 is frequently down-regulated in human cancers. {ECO:0000269|PubMed:16365034, ECO:0000269|PubMed:23217327}.
Top Pathways	Apoptosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

AIF peptide - ab203574 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

AIF peptide - ab7869 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

AIF peptide - ab7870 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

AIF peptide - ab7871 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

Human AIF full length protein - ab160350 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

Human AIF full length protein - ab177656 from Abcam Category Protein Prices $301.00 Sizes 100 µg Source E. coli Species Human

Human AIF peptide - ab97361 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human AIF protein fragment - ab160351 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Pig AIF protein fragment - ab151343 from Abcam Category Protein Source E. coli Species Pig

AIFM1 / AIF / PDCD8 Antibody Blocking Peptide - LS-E10585 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AIFM1 / AIF / PDCD8 Antibody Blocking Peptide - LS-E10613 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AIFM1 / AIF / PDCD8 Antibody Blocking Peptide - LS-E14630 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AIFM1 / AIF / PDCD8 Antibody Blocking Peptide - LS-E29924 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

AIFM1 / AIF / PDCD8 Antibody Blocking Peptide - LS-E29940 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

AIFM1 / AIF / PDCD8 Antibody Blocking Peptide - LS-E9848 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human AIF Protein - H00009131-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

AIF Partial Recombinant Protein - H00009131-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

AIF Blocking Peptide - NBP1-76838PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

AIF Peptide - NBP1-77294PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

AIFM1-Antibody-N-term-Blocking-Peptide - BP8910a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AIF peptide - GTX27869 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

AIF peptide - GTX27870 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

AIF peptide - GTX27871 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

Human AIFM1 protein - orb244009 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

AIF Blocking Peptide - 33R-10667 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

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