EPHA5

Gene Symbol	EPHA5
Entrez Gene	2044
Alt Symbol	CEK7, EHK-1, EHK1, EK7, HEK7, TYRO4
Species	Human
Gene Type	protein-coding
Description	EPH receptor A5
Other Description	EPH homology kinase 1|EPH-like kinase 7|brain-specific kinase|ephrin type-A receptor 5|receptor protein-tyrosine kinase HEK7|tyrosine-protein kinase receptor EHK-1
Swissprots	Q7Z3F2 P54756
Accessions	EAX05536 EAX05537 EAX05538 EAX05539 P54756 AB209375 BAD92612 AK307826 AM393049 CAL37927 AM393488 CAL38365 BC136257 AAI36258 BC136258 AAI36259 BC143427 AAI43428 BX537946 CAD97914 L36644 AAA74245 XM_005265653 XP_005265710 XM_011531733 XP_011530035 XM_011531734 XP_011530036 XM_011531735 XP_011530037 XM_011531736 XP_011530038 NM_001281765 NP_001268694 NM_001281766 NP_001268695 NM_001281767 NP_001268696 NM_004439 NP_004430 NM_182472 NP_872272
Function	Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino- hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose- stimulated insulin secretion (By similarity). {ECO:0000250}.
Subcellular Location	Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000269|PubMed:10375373, ECO:0000269|PubMed:9191074}.
Tissue Specificity	Almost exclusively expressed in the nervous system in cortical neurons, cerebellar Purkinje cells and pyramidal neurons within the cortex and hippocampus. Display an increasing gradient of expression from the forebrain to hindbrain and spinal cord. {ECO:0000269|PubMed:10375373, ECO:0000269|PubMed:9191074}.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Eph receptor A5 protein fragment - ab158372 from Abcam Category Protein Source Wheat germ Species Human

EPHA5 / EPH Receptor A5 Antibody Blocking Peptide - LS-E21383 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EPHA5 / EPH Receptor A5 Antibody Blocking Peptide - LS-E9105 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EPHA5 / EPH Receptor A5 Antibody Blocking Peptide - LS-E9104 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EphA5 Partial Recombinant Protein - H00002044-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

EphA5 Recombinant Protein - P4680 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

EphA5 Peptide - P2623 from Novus Biologicals Category Peptide Species Human

Mouse-Epha5-Antibody-N-term-Blocking-Peptide - BP19463a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg Species Mouse

EphA5-Antibody-N-term-Blocking-Peptide - BP7610a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human EphA5, CF - 3036-A5-100 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ser56-Pro573, with a C-terminal 6-His tag

Eph Receptor A5 Blocking Peptide - 33R-8364 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EPHA5 Blocking Peptide - abx062586 from Abbexa Category Peptide Species Human, Mouse, Rat, Chicken, Monkey

EPHA5 - H00002044-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

EPHA5 - H00002044-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

EPHA5 - P4680 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

EPHA5 - P5706 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

Recombinant Human EPH Receptor A5, GST-tagged - EPHA5-696H from Creative Biomart Category Protein Source Insect cells.

Recombinant Human EPH Receptor A5, GST-His - EPHA5-744H from Creative Biomart Category Protein Source Baculovirus infected Sf9 cells.

Recombinant Human EPHA5 - EPHA5-454H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human EPHA5, His-tagged - EPHA5-364H from Creative Biomart Category Protein Source NSO cells Species Human

EphA5 Protein, active, 250 µg - 14-639M from EMD Millipore Category Protein Prices $2,441.00 Sizes 250 µg also available in 10 μg size . (cat#14-639) and in bulk (cat#14-639-K) Source recombinant human EphA5, amino acids 655-956

EphA5 Protein, active, 10 µg - 14-639 from EMD Millipore Category Protein Prices $315.00 Sizes 10 µg Source recombinant human EphA5, amino acids 655-956

EPHA5 Blocking Peptide - CBP1392 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Chicken, Monkey

EphA5 (Y515) Peptide - BS9185P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Ephrin type-A receptor 5(EPHA5) - CSB-YP007725HU CSB-EP007725HU CSB-BP007725HU CSB-MP007725HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

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