EPHA5

Gene Symbol	EPHA5
Entrez Gene	2044
Alt Symbol	CEK7, EHK-1, EHK1, EK7, HEK7, TYRO4
Species	Human
Gene Type	protein-coding
Description	EPH receptor A5
Other Description	EPH homology kinase 1|EPH-like kinase 7|brain-specific kinase|ephrin type-A receptor 5|receptor protein-tyrosine kinase HEK7|tyrosine-protein kinase receptor EHK-1
Swissprots	Q7Z3F2 P54756
Accessions	EAX05536 EAX05537 EAX05538 EAX05539 P54756 AB209375 BAD92612 AK307826 AM393049 CAL37927 AM393488 CAL38365 BC136257 AAI36258 BC136258 AAI36259 BC143427 AAI43428 BX537946 CAD97914 L36644 AAA74245 XM_005265653 XP_005265710 XM_011531733 XP_011530035 XM_011531734 XP_011530036 XM_011531735 XP_011530037 XM_011531736 XP_011530038 NM_001281765 NP_001268694 NM_001281766 NP_001268695 NM_001281767 NP_001268696 NM_004439 NP_004430 NM_182472 NP_872272
Function	Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino- hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose- stimulated insulin secretion (By similarity). {ECO:0000250}.
Subcellular Location	Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000269|PubMed:10375373, ECO:0000269|PubMed:9191074}.
Tissue Specificity	Almost exclusively expressed in the nervous system in cortical neurons, cerebellar Purkinje cells and pyramidal neurons within the cortex and hippocampus. Display an increasing gradient of expression from the forebrain to hindbrain and spinal cord. {ECO:0000269|PubMed:10375373, ECO:0000269|PubMed:9191074}.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

EphA5 CRISPR/Cas9 KO Plasmid (h) - sc-403104 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

EphA5 HDR Plasmid (h) - sc-403104-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

EphA5 Double Nickase Plasmid (h) - sc-403104-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

EphA5 Double Nickase Plasmid (h2) - sc-403104-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

EphA5 CRISPR Activation Plasmid (h) - sc-403104-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

EphA5 CRISPR Activation Plasmid (h2) - sc-403104-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

EphA5 Lentiviral Activation Particles (h) - sc-403104-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

EphA5 Lentiviral Activation Particles (h2) - sc-403104-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

EphA5 siRNA (h) - sc-39938 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

EphA5 shRNA Plasmid (h) - sc-39938-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

EphA5 shRNA (h) Lentiviral Particles - sc-39938-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

EphA5 RNAi - H00002044-R07 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU161011 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0694 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0693 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0695 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN2220 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2220 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00516 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr00516

EPHA5 siRNA (Human) - CRH1421 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

EphA5 RNAi - H00002044-R08 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

EPHA5 - MBS8201834 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human Epha5 (NM_004439.5) - SHH286393 from Creative biogene Category siRNA Species Reactivities Human

EPHA5 shRNA Plasmid (Human) - CHH1421 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

EPHA5 miRNA 3'UTR clone - MiUTR4H-TG03112 from Creative biogene Species Reactivities Human

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