EPHA5

Gene Symbol EPHA5
Entrez Gene 2044
Alt Symbol CEK7, EHK-1, EHK1, EK7, HEK7, TYRO4
Species Human
Gene Type protein-coding
Description EPH receptor A5
Other Description EPH homology kinase 1|EPH-like kinase 7|brain-specific kinase|ephrin type-A receptor 5|receptor protein-tyrosine kinase HEK7|tyrosine-protein kinase receptor EHK-1
Swissprots Q7Z3F2 P54756
Accessions EAX05536 EAX05537 EAX05538 EAX05539 P54756 AB209375 BAD92612 AK307826 AM393049 CAL37927 AM393488 CAL38365 BC136257 AAI36258 BC136258 AAI36259 BC143427 AAI43428 BX537946 CAD97914 L36644 AAA74245 XM_005265653 XP_005265710 XM_011531733 XP_011530035 XM_011531734 XP_011530036 XM_011531735 XP_011530037 XM_011531736 XP_011530038 NM_001281765 NP_001268694 NM_001281766 NP_001268695 NM_001281767 NP_001268696 NM_004439 NP_004430 NM_182472 NP_872272
Function Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino- hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose- stimulated insulin secretion (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000269|PubMed:10375373, ECO:0000269|PubMed:9191074}.
Tissue Specificity Almost exclusively expressed in the nervous system in cortical neurons, cerebellar Purkinje cells and pyramidal neurons within the cortex and hippocampus. Display an increasing gradient of expression from the forebrain to hindbrain and spinal cord. {ECO:0000269|PubMed:10375373, ECO:0000269|PubMed:9191074}.
Top Pathways Axon guidance

EphA5 (C-16) - sc-927 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
EphA5 (C-16): sc-927. Western blot analysis of EphA5 expression in U-87 MG whole cell lysate.

EphA5 (H-60) - sc-25458 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
EphA5 (H-60): sc-25458. Western blot analysis of EphA5 expression in U-87 MG whole cell lysate.

EphA5 (L-15) - sc-1014 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
EphA5 (L-15): sc-1014. Western blot analysis of EphA5 expression in rat brain tissue extract.

Anti-Eph receptor A5 antibody - ab5397 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab5397 stained SKNSH cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab5397 at 1µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Eph receptor A5 antibody - ab5398 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

Anti-Eph receptor A5 antibody - ab85645 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Eph receptor A5 antibody (ab85645) at 1 µg/ml (in 5% skim milk / PBS buffer) + human fetal brain lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-Eph receptor A5 antibody - ab136116 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Eph receptor A5 antibody (ab136116) at 1/500 dilution + HeLa cell lysate at 30 µg

Anti-Eph receptor A5 antibody [8B10B1,8B10F5] - ab81607 from Abcam

Host Mouse
Clonality Monoclonal
Clone 8B10B1,8B10F5
All lanes : Anti-Eph receptor A5 antibody [8B10B1,8B10F5] (ab81607) at 1/500 dilutionLane 1 : Eph receptor A5 -His recombinant protein Lane 2 : truncated Eph receptor A5 (aa620-774)-hIgGFc transfected CHO-K1 cell lysate

Anti-Eph receptor A5 antibody [EPR15249] - ab198993 from Abcam

Prices $347.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR15249
Immunohistochemical analysis of paraffin-embedded human cerebellum tissue sections labeling Eph receptor A5 with ab198993 at a 1/2000 dilution. Goat anti-rabbit IgG H&L (HRP) ab97051 used as the secondary at a 1/500 dilution. Counterstain hematoxylin.

Anti-EPHA5 / EPH Receptor A5 Antibody (clone 46CT61.6.4) - LS-C96478 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Mouse
Clonality Monoclonal
Clone 46CT61.6.4
Formalin-fixed and paraffin-embedded human brain tissue reacted with EPHA5 Monoclonal Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-EPHA5 / EPH Receptor A5 Antibody (aa188-228) - LS-C6542 from LifeSpan Bioscience

Prices $475.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal

Anti-EPHA5 / EPH Receptor A5 Antibody (aa157-172) - LS-C6541 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-EPHA5 / EPH Receptor A5 Antibody (aa157-172) - LS-C147874 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-EPHA5 / EPH Receptor A5 Antibody (aa114-204, clone 10C98, Azide-free) - LS-C183598 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 10C98

Anti-EPHA5 / EPH Receptor A5 Antibody (Tyr515) - LS-C193185 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-EPHA5 / EPH Receptor A5 Antibody (clone 8B10B1,8B10F5) - LS-C108799 from LifeSpan Bioscience

Prices $320.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 8B10B1,8B10F5
Western blot using EPHA5 mouse monoclonal antibody against truncated EPHA5-His recombinant protein (1) and truncated EPHA5(aa620-774)-hIgGFc transfected CHO-K1 cell lysate(2).

Anti-EPHA5 / EPH Receptor A5 Antibody (clone 5C3) - LS-C197144 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5C3

Anti-EPHA5 / EPH Receptor A5 Antibody (AP) - LS-C225360 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-EPHA5 / EPH Receptor A5 Antibody (APC) - LS-C225361 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-EPHA5 / EPH Receptor A5 Antibody - LS-C100264 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of EphA5 (arrow) using rabbit polyclonal EphA5 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the EphA5 gene (Lane 2) (Origene Technologies).

Anti-EPHA5 / EPH Receptor A5 Antibody (Biotin) - LS-C225362 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-EPHA5 / EPH Receptor A5 Antibody (aa792-841) - LS-C102782 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
EPHA5 antibody LS-C102782 Western blot of Fetal Brain lysate.

Anti-EPHA5 / EPH Receptor A5 Antibody (PE) - LS-C225364 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-EPHA5 / EPH Receptor A5 Antibody (Azide-free, HRP) - LS-C225365 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-EPHA5 / EPH Receptor A5 Antibody (FITC) - LS-C225363 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
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