Prkcb

Gene Symbol Prkcb
Entrez Gene 25023
Alt Symbol Pkcb, Prkcb1
Species Rat
Gene Type protein-coding
Description protein kinase C, beta
Other Description PKC-beta|protein kinase C beta I|protein kinase C beta II|protein kinase C beta type|protein kinase C, beta 1
Swissprots P68403
Accessions AAA41869 CAA28035 EDM17554 EDM17555 EDM17556 EDM17557 P68403 BM383786 CB576043 CK838368 FQ212401 FQ233088 FQ234728 K03485 AAA41864 K03486 AAA41865 M13706 AAA41875 M15522 AAA41876 M19007 AAA41868 X04139 CAA27756 X04440 CAA28036 NM_001172305 NP_001165776 NM_012713 NP_036845
Function Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration
Subcellular Location Cytoplasm. Nucleus {ECO:0000250}. Membrane; Peripheral membrane protein.
Top Pathways Wnt signaling pathway, Tight junction, VEGF signaling pathway, Focal adhesion, Gap junction

Monoclonal Anti-Protein Kinase Cβ2 antibody produced in mouse - P2584 from Sigma-Aldrich

Prices $301.50
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone PK-B26

PRKCB antibody - PAB13634 from Acris Antibodies

Prices $420.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PRKCB antibody - PAB13636 from Acris Antibodies

Prices $420.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Protein Kinase C Beta 1 (PKCb1) - 20-3521 from ARP American Research Products

Prices $359.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

PKC Beta 2, Polyclonal Antibody - MBS352215 from MyBioSource

Prices $300.00
Sizes 1 bottle
Host Rabbit
Clonality Polyclonal

PKC Beta 2, Polyclonal Antibody - MBS352216 from MyBioSource

Prices $270.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PKC Beta 2 (Rat), Polyclonal Antibody - MBS352217 from MyBioSource

Prices $400.00
Sizes 100 µl
Host Rat
Clonality Polyclonal

Protein Kinase C beta1, Polyclonal Antibody - MBS613159 from MyBioSource

Prices $755.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Protein Kinase C beta1, Polyclonal Antibody - MBS615518 from MyBioSource

Prices $525.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Protein Kinase C beta1, Polyclonal Antibody - MBS610447 from MyBioSource

Prices $390.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Protein Kinase C, beta 1 - MBS624720 from MyBioSource

Prices $380.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Protein Kinase C, beta1 - MBS611078 from MyBioSource

Prices $545.00
Sizes 10 blots
Host Rabbit
Clonality Polyclonal

Monoclonal Antibody to Protein Kinase C Beta 1 (PKCb1) - MAB045Ra21 from Cloud-clone

Host Mouse
Clonality Monoclonal

Polyclonal Antibody to Protein Kinase C Beta 1 (PKCb1) - PAB045Ra01 from Cloud-clone

Host Rabbit
Clonality Polyclonal

Biotin-Linked Antibody to Protein Kinase C Beta 1 (PKCb1) - PAB045Ra71 from Cloud-clone

Host Rabbit
Clonality Polyclonal

FITC-Linked Antibody to Protein Kinase C Beta 1 (PKCb1) - PAB045Ra81 from Cloud-clone

Host Rabbit
Clonality Polyclonal

Anti-Protein Kinase Cβ 2 antibody produced in rabbit - P3203 from Sigma-Aldrich

Prices $333.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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