Prkcb

Gene Symbol Prkcb
Entrez Gene 25023
Alt Symbol Pkcb, Prkcb1
Species Rat
Gene Type protein-coding
Description protein kinase C, beta
Other Description PKC-beta|protein kinase C beta I|protein kinase C beta II|protein kinase C beta type|protein kinase C, beta 1
Swissprots P68403
Accessions AAA41869 CAA28035 EDM17554 EDM17555 EDM17556 EDM17557 P68403 BM383786 CB576043 CK838368 FQ212401 FQ233088 FQ234728 K03485 AAA41864 K03486 AAA41865 M13706 AAA41875 M15522 AAA41876 M19007 AAA41868 X04139 CAA27756 X04440 CAA28036 NM_001172305 NP_001165776 NM_012713 NP_036845
Function Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration
Subcellular Location Cytoplasm. Nucleus {ECO:0000250}. Membrane; Peripheral membrane protein.
Top Pathways Wnt signaling pathway, Tight junction, VEGF signaling pathway, Focal adhesion, Gap junction

Rat PKCb1 Protein - abx068749 from Abbexa

Category Protein
Source E.coli
Species Rat

Protein Kinase C Beta 1 (PKCb1), Rat - 20-7429 from ARP American Research Products

Category Protein
Prices $309.00
Sizes 50 µg
Source E.coli
Species Rat

Recombinant Protein Kinase C Beta 1 (PKCb1) - RPB045Ra01 from Cloud-clone

Category Protein
Source E.coli
Species Rat

Recombinant Rat Protein kinase C beta type(Prkcb) - CSB-YP018700RA CSB-EP018700RA CSB-BP018700RA CSB-MP018700RA from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Rat

Recombinant Rat PRKCB Protein - PRKCB-4677R from Creative Biomart

Category Protein
Source Mammalian Cells
Species Rat

PRKCB Recombinant Protein (OPCD06211) - OPCD06211 from Aviva Systems Biology

Category Protein
Source E.coli
Species Rat

Protein Kinase C Beta 1 (PKCb1), Recombinant Protein - MBS2010956 from MyBioSource

Category Protein
Prices $130.00, $230.00, $345.00
Sizes 10 µg, 50 µg, 100 µg
Source Prokaryotic expression
Species Rat

Protein kinase C beta type (Prkcb), Recombinant Protein - MBS1174908 from MyBioSource

Category Protein
Prices $1,470.00, $1,470.00, $1,700.00, $1,700.00, $2,510.00, $2,510.00, $2,950.00, $2,950.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Rat
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