| Gene Symbol |
Prkcb
|
| Entrez Gene |
25023
|
| Alt Symbol |
Pkcb, Prkcb1
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
protein kinase C, beta
|
| Other Description |
PKC-beta|protein kinase C beta I|protein kinase C beta II|protein kinase C beta type|protein kinase C, beta 1
|
| Swissprots |
P68403
|
| Accessions |
AAA41869 CAA28035 EDM17554 EDM17555 EDM17556 EDM17557 P68403 BM383786 CB576043 CK838368 FQ212401 FQ233088 FQ234728 K03485 AAA41864 K03486 AAA41865 M13706 AAA41875 M15522 AAA41876 M19007 AAA41868 X04139 CAA27756 X04440 CAA28036 NM_001172305 NP_001165776 NM_012713 NP_036845
|
| Function |
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration
|
| Subcellular Location |
Cytoplasm. Nucleus {ECO:0000250}. Membrane; Peripheral membrane protein.
|
| Top Pathways |
Wnt signaling pathway, Tight junction, VEGF signaling pathway, Focal adhesion, Gap junction
|