Gene Symbol | SRI |
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Entrez Gene | 6717 |
Alt Symbol | CP-22, CP22, SCN, V19 |
Species | Human |
Gene Type | protein-coding |
Description | sorcin |
Other Description | 22 kDa protein|H_RG167B05.1|calcium binding protein amplified in mutlidrug-resistant cells |
Swissprots | B4DKK2 P30626 D6W5Q0 A8MTH6 |
Accessions | AAB96327 EAW76909 EAW76910 EAW76911 P30626 AK129770 AK295225 BAG58218 AK296601 BAG59214 AK310366 AL039198 AL117616 AL576812 BC011025 AAH11025 BI524104 BI559592 BI597920 BM739144 BM793972 BU854353 DA268050 DB540255 L12387 AAA92155 M32886 AAA60588 XM_006716097 XP_006716160 XM_011516528 XP_011514830 NM_001256891 NP_001243820 NM_001256892 NP_001243821 NM_003130 NP_003121 NM_198901 NP_944490 |
Function | Calcium-binding protein that modulates excitation- contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. {ECO:0000269|PubMed:17699613}. |
Subcellular Location | Cytoplasm. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels. |
Tissue Specificity | Detected in cardiac myocytes. |
sorcin (C-20) - sc-12301 from Santa Cruz Biotechnology
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sorcin (39-M) - sc-100859 from Santa Cruz Biotechnology
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Anti-SR1 antibody - ab57991 from Abcam
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Anti-SRI / Sorcin Antibody (clone 1E12) - LS-C198259 from LifeSpan Bioscience
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Anti-SRI / Sorcin Antibody (aa50-100) IHC-plus⢠- LS-B1793 from LifeSpan Bioscience
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Anti-SRI / Sorcin Antibody (C-Terminus) - LS-C146026 from LifeSpan Bioscience
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Anti-SRI / Sorcin Antibody (aa96-145) - LS-C146025 from LifeSpan Bioscience
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SR1 Antibody (1E12.) - H00006717-M01 from Novus Biologicals
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SR1 Antibody - NBP1-32340 from Novus Biologicals
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SR1 Antibody - NBP1-39746 from Novus Biologicals
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Sorcin Polyclonal Antibody - bs-9871R from Bioss
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Monoclonal Anti-SRI antibody produced in mouse - WH0006717M1 from Sigma-Aldrich
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Anti-SRI (127-140) antibody produced in rabbit - SAB1105144 from Sigma-Aldrich
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Anti-SRI (152-165) antibody produced in rabbit - SAB1105145 from Sigma-Aldrich
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Anti-SRI antibody produced in rabbit - SAB2107744 from Sigma-Aldrich
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Anti-SRI antibody produced in rabbit - SAB2700316 from Sigma-Aldrich
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SRI antibody - middle region (ARP62986_P050) - ARP62986_P050 from Aviva Systems Biology
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SRI antibody - C-terminal region (ARP62987_P050) - ARP62987_P050 from Aviva Systems Biology
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SRI-Antibody-monoclonal-M01 - AT4040a from Abgent, a WuXi AppTec company
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SRI antibody - 70R-20520 from Fitzgerald
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SRI Antibody (OALA02145) - OALA02145 from Aviva Systems Biology
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Sorcin Antibody - abx115730 from Abbexa
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Sorcin / SRI antibody - 16471-1-AP from Acris Antibodies
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Sorcin / SRI antibody - H00006717-M01 from Acris Antibodies
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Sorcin / SRI (50-100) antibody - AP08275PU-N from Acris Antibodies
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