SRI
| Gene Symbol | SRI |
|---|---|
| Entrez Gene | 6717 |
| Alt Symbol | CP-22, CP22, SCN, V19 |
| Species | Human |
| Gene Type | protein-coding |
| Description | sorcin |
| Other Description | 22 kDa protein|H_RG167B05.1|calcium binding protein amplified in mutlidrug-resistant cells |
| Swissprots | B4DKK2 P30626 D6W5Q0 A8MTH6 |
| Accessions | AAB96327 EAW76909 EAW76910 EAW76911 P30626 AK129770 AK295225 BAG58218 AK296601 BAG59214 AK310366 AL039198 AL117616 AL576812 BC011025 AAH11025 BI524104 BI559592 BI597920 BM739144 BM793972 BU854353 DA268050 DB540255 L12387 AAA92155 M32886 AAA60588 XM_006716097 XP_006716160 XM_011516528 XP_011514830 NM_001256891 NP_001243820 NM_001256892 NP_001243821 NM_003130 NP_003121 NM_198901 NP_944490 |
| Function | Calcium-binding protein that modulates excitation- contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. {ECO:0000269|PubMed:17699613}. |
| Subcellular Location | Cytoplasm. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels. |
| Tissue Specificity | Detected in cardiac myocytes. |
sorcin CRISPR/Cas9 KO Plasmid (h) - sc-416929 from Santa Cruz Biotechnology
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sorcin HDR Plasmid (h) - sc-416929-HDR from Santa Cruz Biotechnology
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sorcin Double Nickase Plasmid (h) - sc-416929-NIC from Santa Cruz Biotechnology
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sorcin Double Nickase Plasmid (h2) - sc-416929-NIC-2 from Santa Cruz Biotechnology
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sorcin CRISPR Activation Plasmid (h) - sc-416929-ACT from Santa Cruz Biotechnology
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sorcin CRISPR Activation Plasmid (h2) - sc-416929-ACT-2 from Santa Cruz Biotechnology
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sorcin Lentiviral Activation Particles (h) - sc-416929-LAC from Santa Cruz Biotechnology
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sorcin Lentiviral Activation Particles (h2) - sc-416929-LAC-2 from Santa Cruz Biotechnology
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sorcin siRNA (h) - sc-41016 from Santa Cruz Biotechnology
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sorcin shRNA Plasmid (h) - sc-41016-SH from Santa Cruz Biotechnology
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sorcin shRNA (h) Lentiviral Particles - sc-41016-V from Santa Cruz Biotechnology
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SR1 RNAi - H00006717-R01 from Novus Biologicals
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SR1 RNAi - H00006717-R02 from Novus Biologicals
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MISSION® esiRNA - EHU079901 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20574 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20574 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09396 from Sigma-Aldrich
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SRI siRNA (Human) - CRH4586 from Cohesion Biosciences
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SRI - MBS8237327 from MyBioSource
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shRNA set against Human SRI (NM_003130.3) - SHH417848 from Creative biogene
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shRNA set against Human SRI(NM_198901.1) - SHL034568 from Creative biogene
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Human SRI siRNA - orb265088 from Biorbyt
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SRI shRNA Plasmid (Human) - CHH4586 from Cohesion Biosciences
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SRI miRNA 3'UTR clone - MiUTR1H-09905 from Creative biogene
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SRI miRNA 3'UTR clone - MiUTR3H-02124 from Creative biogene
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