Gene Symbol | Wwox |
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Entrez Gene | 80707 |
Alt Symbol | 5330426P09Rik, 9030416C10Rik, WOX1 |
Species | Mouse |
Gene Type | protein-coding |
Description | WW domain-containing oxidoreductase |
Other Description | WW-domain oxidoreductase |
Swissprots | Q920Y2 Q9JLF5 Q8C8J6 Q91WL8 Q9D339 Q9D2B3 |
Accessions | EDL11554 Q91WL8 AF187014 AAF31693 AK018507 BAB31244 AK019911 BAB31911 AK046903 BAC32916 AK050541 AK078528 BAC37325 AK083096 BC014716 AAH14716 BM218596 CJ058964 EF410109 XM_006531510 XP_006531573 XM_006531511 XP_006531574 XM_006531512 XP_006531575 XM_006531513 XP_006531576 XM_006531514 XP_006531577 XM_006531515 XP_006531578 XM_011248556 XP_011246858 XM_011248557 XP_011246859 XM_011248558 XP_011246860 NM_019573 NP_062519 |
Function | Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm (By similarity). May also play a role in tumor necrosis factor (TNF)- mediated cell death. Required for normal bone development. {ECO:0000250, ECO:0000269|PubMed:11058590, ECO:0000269|PubMed:19366691}. |
Subcellular Location | Cytoplasm. Nucleus. Mitochondrion {ECO:0000250}. Note=Partially localizes to the mitochondria (By similarity). Translocates to the nucleus in response to TGFB1 (By similarity). Translocates to the nucleus upon genotoxic stress or TNF stimulation. {ECO:0000250}. |
Tissue Specificity | Ubiquitous. In the brain, expressed in cortex, striatum, hippocampus and cerebellum (at protein level). Detected in embryonic skeleton, in cranofacial bones, vertebrae and limb bones. Detected in chondrocytes and osteoblasts. {ECO:0000269|PubMed:15026124, ECO:0000269|PubMed:17360458, ECO:0000269|PubMed:18487609}. |
WW domain-containing oxidoreductase (WWOX), Mouse, ELISA Kit - E03W0017 from ARP American Research Products
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WW domain-containing oxidoreductase, ELISA Kit - MBS280429 from MyBioSource
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WW domain-containing oxidoreductase (WWOX), ELISA Kit - MBS7233864 from MyBioSource
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WW domain-containing oxidoreductase (WWOX), ELISA Kit - MBS7207248 from MyBioSource
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WW domain-containing oxidoreductase (WWOX), ELISA Kit - MBS7212919 from MyBioSource
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WW domain-containing oxidoreductase (WWOX), ELISA Kit - MBS7249041 from MyBioSource
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WW domain-containing oxidoreductase (WWOX), ELISA Kit - MBS7214523 from MyBioSource
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WW domain-containing oxidoreductase (WWOX), ELISA Kit - MBS7225281 from MyBioSource
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WW domain-containing oxidoreductase (WWOX), ELISA Kit - MBS7229904 from MyBioSource
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WW domain-containing oxidoreductase (WWOX), ELISA Kit - MBS7208403 from MyBioSource
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WW domain-containing oxidoreductase (WWOX), ELISA Kit - MBS7218937 from MyBioSource
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WW domain-containing oxidoreductase (WWOX), ELISA Kit - MBS7219199 from MyBioSource
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Mouse Wwox ELISA Kit - E072865 from Biobool
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