Wwox

Gene Symbol Wwox
Entrez Gene 80707
Alt Symbol 5330426P09Rik, 9030416C10Rik, WOX1
Species Mouse
Gene Type protein-coding
Description WW domain-containing oxidoreductase
Other Description WW-domain oxidoreductase
Swissprots Q920Y2 Q9JLF5 Q8C8J6 Q91WL8 Q9D339 Q9D2B3
Accessions EDL11554 Q91WL8 AF187014 AAF31693 AK018507 BAB31244 AK019911 BAB31911 AK046903 BAC32916 AK050541 AK078528 BAC37325 AK083096 BC014716 AAH14716 BM218596 CJ058964 EF410109 XM_006531510 XP_006531573 XM_006531511 XP_006531574 XM_006531512 XP_006531575 XM_006531513 XP_006531576 XM_006531514 XP_006531577 XM_006531515 XP_006531578 XM_011248556 XP_011246858 XM_011248557 XP_011246859 XM_011248558 XP_011246860 NM_019573 NP_062519
Function Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm (By similarity). May also play a role in tumor necrosis factor (TNF)- mediated cell death. Required for normal bone development. {ECO:0000250, ECO:0000269|PubMed:11058590, ECO:0000269|PubMed:19366691}.
Subcellular Location Cytoplasm. Nucleus. Mitochondrion {ECO:0000250}. Note=Partially localizes to the mitochondria (By similarity). Translocates to the nucleus in response to TGFB1 (By similarity). Translocates to the nucleus upon genotoxic stress or TNF stimulation. {ECO:0000250}.
Tissue Specificity Ubiquitous. In the brain, expressed in cortex, striatum, hippocampus and cerebellum (at protein level). Detected in embryonic skeleton, in cranofacial bones, vertebrae and limb bones. Detected in chondrocytes and osteoblasts. {ECO:0000269|PubMed:15026124, ECO:0000269|PubMed:17360458, ECO:0000269|PubMed:18487609}.

WWOX CRISPR/Cas9 KO Plasmid (m) - sc-429800 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

WWOX HDR Plasmid (m) - sc-429800-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

WWOX Double Nickase Plasmid (m) - sc-429800-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

WWOX Double Nickase Plasmid (m2) - sc-429800-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

WWOX CRISPR Activation Plasmid (m) - sc-429800-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

WWOX CRISPR Activation Plasmid (m2) - sc-429800-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

WWOX Lentiviral Activation Particles (m) - sc-429800-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

WWOX Lentiviral Activation Particles (m2) - sc-429800-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

WWOX siRNA (m) - sc-155368 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

WWOX shRNA Plasmid (m) - sc-155368-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

WWOX shRNA (m) Lentiviral Particles - sc-155368-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU040171 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN44700 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND44700 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

WWOX siRNA (Mouse) - CRN0054 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

WWOX - MBS8222350 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse WWOX (NM_019573.3) - SHH447596 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse WWOX siRNA - orb289529 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

WWOX shRNA Plasmid (Mouse) - CHN0054 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse
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