| Gene Symbol |
Wwox
|
| Entrez Gene |
80707
|
| Alt Symbol |
5330426P09Rik, 9030416C10Rik, WOX1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
WW domain-containing oxidoreductase
|
| Other Description |
WW-domain oxidoreductase
|
| Swissprots |
Q920Y2 Q9JLF5 Q8C8J6 Q91WL8 Q9D339 Q9D2B3
|
| Accessions |
EDL11554 Q91WL8 AF187014 AAF31693 AK018507 BAB31244 AK019911 BAB31911 AK046903 BAC32916 AK050541 AK078528 BAC37325 AK083096 BC014716 AAH14716 BM218596 CJ058964 EF410109 XM_006531510 XP_006531573 XM_006531511 XP_006531574 XM_006531512 XP_006531575 XM_006531513 XP_006531576 XM_006531514 XP_006531577 XM_006531515 XP_006531578 XM_011248556 XP_011246858 XM_011248557 XP_011246859 XM_011248558 XP_011246860 NM_019573 NP_062519
|
| Function |
Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm (By similarity). May also play a role in tumor necrosis factor (TNF)- mediated cell death. Required for normal bone development. {ECO:0000250, ECO:0000269|PubMed:11058590, ECO:0000269|PubMed:19366691}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Mitochondrion {ECO:0000250}. Note=Partially localizes to the mitochondria (By similarity). Translocates to the nucleus in response to TGFB1 (By similarity). Translocates to the nucleus upon genotoxic stress or TNF stimulation. {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitous. In the brain, expressed in cortex, striatum, hippocampus and cerebellum (at protein level). Detected in embryonic skeleton, in cranofacial bones, vertebrae and limb bones. Detected in chondrocytes and osteoblasts. {ECO:0000269|PubMed:15026124, ECO:0000269|PubMed:17360458, ECO:0000269|PubMed:18487609}.
|