| Gene Symbol |
RCE1
|
| Entrez Gene |
9986
|
| Alt Symbol |
FACE2, RCE1A, RCE1B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Ras converting CAAX endopeptidase 1
|
| Other Description |
CAAX prenyl protease 2|RCE1 homolog, prenyl protein peptidase|farnesylated protein-converting enzyme 2|farnesylated proteins-converting enzyme 2|prenyl protein-specific endoprotease 2
|
| Swissprots |
Q52LZ9 Q9Y256
|
| Accessions |
CAH05639 EAW74565 EAW74566 EAW74567 Q9Y256 AF121951 AAD22632 AL713740 BC052622 AAH52622 BC093726 AAH93726 BC093728 AAH93728 Y13835 CAB46278 NM_001032279 NP_001027450 NM_005133 NP_005124
|
| Function |
Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:19188362}; Multi-pass membrane protein {ECO:0000269|PubMed:19188362}.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
Terpenoid backbone biosynthesis
|