Gene Symbol | RCE1 |
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Entrez Gene | 9986 |
Alt Symbol | FACE2, RCE1A, RCE1B |
Species | Human |
Gene Type | protein-coding |
Description | Ras converting CAAX endopeptidase 1 |
Other Description | CAAX prenyl protease 2|RCE1 homolog, prenyl protein peptidase|farnesylated protein-converting enzyme 2|farnesylated proteins-converting enzyme 2|prenyl protein-specific endoprotease 2 |
Swissprots | Q52LZ9 Q9Y256 |
Accessions | CAH05639 EAW74565 EAW74566 EAW74567 Q9Y256 AF121951 AAD22632 AL713740 BC052622 AAH52622 BC093726 AAH93726 BC093728 AAH93728 Y13835 CAB46278 NM_001032279 NP_001027450 NM_005133 NP_005124 |
Function | Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:19188362}; Multi-pass membrane protein {ECO:0000269|PubMed:19188362}. |
Tissue Specificity | Ubiquitous. |
Top Pathways | Terpenoid backbone biosynthesis |
RCE1 CRISPR/Cas9 KO Plasmid (h) - sc-408177 from Santa Cruz Biotechnology
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RCE1 HDR Plasmid (h) - sc-408177-HDR from Santa Cruz Biotechnology
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RCE1 Double Nickase Plasmid (h) - sc-408177-NIC from Santa Cruz Biotechnology
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RCE1 Double Nickase Plasmid (h2) - sc-408177-NIC-2 from Santa Cruz Biotechnology
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RCE1 CRISPR Activation Plasmid (h) - sc-408177-ACT from Santa Cruz Biotechnology
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RCE1 CRISPR Activation Plasmid (h2) - sc-408177-ACT-2 from Santa Cruz Biotechnology
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RCE1 Lentiviral Activation Particles (h) - sc-408177-LAC from Santa Cruz Biotechnology
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RCE1 Lentiviral Activation Particles (h2) - sc-408177-LAC-2 from Santa Cruz Biotechnology
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RCE1 siRNA (h) - sc-106496 from Santa Cruz Biotechnology
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RCE1 shRNA Plasmid (h) - sc-106496-SH from Santa Cruz Biotechnology
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RCE1 shRNA (h) Lentiviral Particles - sc-106496-V from Santa Cruz Biotechnology
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RCE1 RNAi - H00009986-R01 from Novus Biologicals
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RCE1 RNAi - H00009986-R03 from Novus Biologicals
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MISSION® esiRNA - EHU156071 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18097 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18097 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03794 from Sigma-Aldrich
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RCE1 siRNA (Human) - CRH6718 from Cohesion Biosciences
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RCE1 RNAi - H00009986-R02 from Novus Biologicals
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RCE1 - MBS827799 from MyBioSource
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shRNA set against Human RCE1 (NM_005133.2) - SHH391277 from Creative biogene
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shRNA set against Human RCE1(NM_001032279.1) - SHR173232 from Creative biogene
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shRNA set against Human RCE1(NM_005133.2) - SHR173416 from Creative biogene
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shRNA set against Human RCE1(NM_001032279.1) - SHR173452 from Creative biogene
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RCE1 shRNA Plasmid (Human) - CHH6718 from Cohesion Biosciences
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