| Gene Symbol | FCGR1A |
|---|---|
| Entrez Gene | 2209 |
| Alt Symbol | CD64, CD64A, FCRI, IGFR1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | Fc fragment of IgG, high affinity Ia, receptor (CD64) |
| Other Description | Fc fragment of IgG, high affinity Ia, receptor for (CD64)|Fc gamma receptor|Fc-gamma RI|Fc-gamma receptor I A1|IgG Fc receptor I|fc-gamma RIA|fcgammaRIa|high affinity immunoglobulin gamma Fc receptor I |
| Swissprots | Q92495 Q92663 P12314 Q5QNW7 P12315 |
| Accessions | AAA35678 AAA58414 AAD13842 CAI12556 CAI12557 P12314 AK291451 BAF84140 AK291502 BAF84191 BC032634 AAH32634 BC152383 AAI52384 DC320241 DQ786309 DQ890842 ABM81768 DQ893997 ABM84923 L03418 AAA36049 X14355 CAA32536 X14356 CAA32537 XM_005244957 XP_005245014 XM_005244958 XP_005245015 NM_000566 NP_000557 |
| Function | High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. {ECO:0000269|PubMed:10397749, ECO:0000269|PubMed:10514529, ECO:0000269|PubMed:21965667, ECO:0000269|PubMed:8611682, ECO:0000269|PubMed:9881690}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:12756162, ECO:0000269|PubMed:8611682}; Single-pass type I membrane protein {ECO:0000269|PubMed:12756162, ECO:0000269|PubMed:8611682}. Note=Stabilized at the cell membrane through interaction with FCER1G. |
| Tissue Specificity | Monocyte/macrophage specific. |
| Top Pathways | Phagosome, Staphylococcus aureus infection, Leishmaniasis, Osteoclast differentiation, Fc gamma R-mediated phagocytosis |