Gene Symbol | FCGR1A |
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Entrez Gene | 2209 |
Alt Symbol | CD64, CD64A, FCRI, IGFR1 |
Species | Human |
Gene Type | protein-coding |
Description | Fc fragment of IgG, high affinity Ia, receptor (CD64) |
Other Description | Fc fragment of IgG, high affinity Ia, receptor for (CD64)|Fc gamma receptor|Fc-gamma RI|Fc-gamma receptor I A1|IgG Fc receptor I|fc-gamma RIA|fcgammaRIa|high affinity immunoglobulin gamma Fc receptor I |
Swissprots | Q92495 Q92663 P12314 Q5QNW7 P12315 |
Accessions | AAA35678 AAA58414 AAD13842 CAI12556 CAI12557 P12314 AK291451 BAF84140 AK291502 BAF84191 BC032634 AAH32634 BC152383 AAI52384 DC320241 DQ786309 DQ890842 ABM81768 DQ893997 ABM84923 L03418 AAA36049 X14355 CAA32536 X14356 CAA32537 XM_005244957 XP_005245014 XM_005244958 XP_005245015 NM_000566 NP_000557 |
Function | High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. {ECO:0000269|PubMed:10397749, ECO:0000269|PubMed:10514529, ECO:0000269|PubMed:21965667, ECO:0000269|PubMed:8611682, ECO:0000269|PubMed:9881690}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:12756162, ECO:0000269|PubMed:8611682}; Single-pass type I membrane protein {ECO:0000269|PubMed:12756162, ECO:0000269|PubMed:8611682}. Note=Stabilized at the cell membrane through interaction with FCER1G. |
Tissue Specificity | Monocyte/macrophage specific. |
Top Pathways | Phagosome, Staphylococcus aureus infection, Leishmaniasis, Osteoclast differentiation, Fc gamma R-mediated phagocytosis |
Human FCGR1A full length protein - ab114416 from Abcam
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Human FCGR1A protein fragment - ab114415 from Abcam
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Human FCGR1A protein fragment - ab134523 from Abcam
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FCGR1A / CD64 Antibody Blocking Peptide - LS-E7651 from LifeSpan Bioscience
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FCGR1A / CD64 Antibody Blocking Peptide - LS-E23322 from LifeSpan Bioscience
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Fc gamma RI/CD64 Partial Recombinant Protein - H00002209-Q01 from Novus Biologicals
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Fc gamma RI/CD64 Recombinant Protein - H00002209-P01 from Novus Biologicals
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Recombinant Human Fc gamma RI/CD64 Protein - NBP2-23044 from Novus Biologicals
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Recombinant Human Fc gamma RI/CD64 Protein - H00002209-G01 from Novus Biologicals
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FCGR1A-Antibody-Center-Blocking-Peptide - BP4930c from Abgent, a WuXi AppTec company
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Recombinant Human Fc gamma RI/CD64, CF - 1257-FC-050 from R&D Systems
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Human FCGR1A protein - orb168333 from Biorbyt
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FCGR1A protein (His tag) - 80R-2486 from Fitzgerald
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Human FcgRI Protein - abx068829 from Abbexa
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CD64 / FCGR1A (16-292, His-tag) - AR50558PU-N from Acris Antibodies
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CD64 / FCGR1A (16-292, His-tag) - AR50558PU-S from Acris Antibodies
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CD64 / FCGR1A - H00002209-G01 from Acris Antibodies
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CD64 / FCGR1A - H00002209-P01-10 from Acris Antibodies
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CD64 / FCGR1A - H00002209-P01-25 from Acris Antibodies
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CD64 / FCGR1A - H00002209-Q01-10 from Acris Antibodies
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CD64 / FCGR1A - H00002209-Q01-25 from Acris Antibodies
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FCGR1A, 16-292aa, Human, His tag, E.coli - 01-P1734 from ARP American Research Products
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FCGR1A Recombinant Protein - 96-305 from ProSci
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FCGR1A fusion protein - Ag11939 from Proteintech Group
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FCGR1A fusion protein - ag11388 from Proteintech Group
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