Gene Symbol | FCGR1A |
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Entrez Gene | 2209 |
Alt Symbol | CD64, CD64A, FCRI, IGFR1 |
Species | Human |
Gene Type | protein-coding |
Description | Fc fragment of IgG, high affinity Ia, receptor (CD64) |
Other Description | Fc fragment of IgG, high affinity Ia, receptor for (CD64)|Fc gamma receptor|Fc-gamma RI|Fc-gamma receptor I A1|IgG Fc receptor I|fc-gamma RIA|fcgammaRIa|high affinity immunoglobulin gamma Fc receptor I |
Swissprots | Q92495 Q92663 P12314 Q5QNW7 P12315 |
Accessions | AAA35678 AAA58414 AAD13842 CAI12556 CAI12557 P12314 AK291451 BAF84140 AK291502 BAF84191 BC032634 AAH32634 BC152383 AAI52384 DC320241 DQ786309 DQ890842 ABM81768 DQ893997 ABM84923 L03418 AAA36049 X14355 CAA32536 X14356 CAA32537 XM_005244957 XP_005245014 XM_005244958 XP_005245015 NM_000566 NP_000557 |
Function | High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. {ECO:0000269|PubMed:10397749, ECO:0000269|PubMed:10514529, ECO:0000269|PubMed:21965667, ECO:0000269|PubMed:8611682, ECO:0000269|PubMed:9881690}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:12756162, ECO:0000269|PubMed:8611682}; Single-pass type I membrane protein {ECO:0000269|PubMed:12756162, ECO:0000269|PubMed:8611682}. Note=Stabilized at the cell membrane through interaction with FCER1G. |
Tissue Specificity | Monocyte/macrophage specific. |
Top Pathways | Phagosome, Staphylococcus aureus infection, Leishmaniasis, Osteoclast differentiation, Fc gamma R-mediated phagocytosis |
CD64 CRISPR/Cas9 KO Plasmid (h) - sc-418273 from Santa Cruz Biotechnology
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CD64 HDR Plasmid (h) - sc-418273-HDR from Santa Cruz Biotechnology
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CD64 Double Nickase Plasmid (h) - sc-418273-NIC from Santa Cruz Biotechnology
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CD64 Double Nickase Plasmid (h2) - sc-418273-NIC-2 from Santa Cruz Biotechnology
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CD64 CRISPR Activation Plasmid (h) - sc-418273-ACT from Santa Cruz Biotechnology
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CD64 CRISPR Activation Plasmid (h2) - sc-418273-ACT-2 from Santa Cruz Biotechnology
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CD64 Lentiviral Activation Particles (h) - sc-418273-LAC from Santa Cruz Biotechnology
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CD64 Lentiviral Activation Particles (h2) - sc-418273-LAC-2 from Santa Cruz Biotechnology
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CD64 siRNA (h) - sc-35017 from Santa Cruz Biotechnology
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CD64 shRNA Plasmid (h) - sc-35017-SH from Santa Cruz Biotechnology
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CD64 shRNA (h) Lentiviral Particles - sc-35017-V from Santa Cruz Biotechnology
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Fc gamma RI/CD64 RNAi - H00002209-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN8586 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8586 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00008 from Sigma-Aldrich
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FCGR1A siRNA (Human) - CRH1544 from Cohesion Biosciences
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FCGR1A - MBS8215765 from MyBioSource
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shRNA set against Human FCGR1A(NM_000566.3) - SHH054227 from Creative biogene
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Human FCGR1A siRNA - orb262046 from Biorbyt
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FCGR1A shRNA Plasmid (Human) - CHH1544 from Cohesion Biosciences
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FCGR1A miRNA 3'UTR clone - MiUTR1H-03594 from Creative biogene
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