| Gene Symbol |
FCGR1A
|
| Entrez Gene |
2209
|
| Alt Symbol |
CD64, CD64A, FCRI, IGFR1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Fc fragment of IgG, high affinity Ia, receptor (CD64)
|
| Other Description |
Fc fragment of IgG, high affinity Ia, receptor for (CD64)|Fc gamma receptor|Fc-gamma RI|Fc-gamma receptor I A1|IgG Fc receptor I|fc-gamma RIA|fcgammaRIa|high affinity immunoglobulin gamma Fc receptor I
|
| Swissprots |
Q92495 Q92663 P12314 Q5QNW7 P12315
|
| Accessions |
AAA35678 AAA58414 AAD13842 CAI12556 CAI12557 P12314 AK291451 BAF84140 AK291502 BAF84191 BC032634 AAH32634 BC152383 AAI52384 DC320241 DQ786309 DQ890842 ABM81768 DQ893997 ABM84923 L03418 AAA36049 X14355 CAA32536 X14356 CAA32537 XM_005244957 XP_005245014 XM_005244958 XP_005245015 NM_000566 NP_000557
|
| Function |
High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. {ECO:0000269|PubMed:10397749, ECO:0000269|PubMed:10514529, ECO:0000269|PubMed:21965667, ECO:0000269|PubMed:8611682, ECO:0000269|PubMed:9881690}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:12756162, ECO:0000269|PubMed:8611682}; Single-pass type I membrane protein {ECO:0000269|PubMed:12756162, ECO:0000269|PubMed:8611682}. Note=Stabilized at the cell membrane through interaction with FCER1G.
|
| Tissue Specificity |
Monocyte/macrophage specific.
|
| Top Pathways |
Phagosome, Staphylococcus aureus infection, Leishmaniasis, Osteoclast differentiation, Fc gamma R-mediated phagocytosis
|
![Western Blot: CD64 Overexpression Lysate (Adult Normal) [NBL1-10654] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CD64.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7399_CD64%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10654-img0002.jpg)