Gene Symbol | LMX1A |
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Entrez Gene | 4009 |
Alt Symbol | LMX1, LMX1.1 |
Species | Human |
Gene Type | protein-coding |
Description | LIM homeobox transcription factor 1, alpha |
Other Description | LIM homeobox transcription factor 1-alpha|LIM/homeobox protein 1.1 |
Swissprots | Q8TE11 Q0VDB5 B3KXP6 Q5VWG4 Q8TE12 |
Accessions | AAL82892 AAL82893 CAL40521 EAW90743 EAW90744 Q8TE12 AK122800 AK127724 BAG54558 BC066353 AAH66353 BC119743 AAI19744 BC119744 AAI19745 BC160062 AAI60062 BM678780 JF432394 ADZ15611 XM_011509538 XP_011507840 XM_011509539 XP_011507841 XM_011509540 XP_011507842 NM_001033507 NM_177399 NM_001174069 NP_001167540 NM_177398 NP_796372 |
Function | Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}. |
Tissue Specificity | Isoform 1 is expressed in many tissues. Not found in heart, liver, spleen and testis. Relatively highly expressed in fetal brain. Isoform LMX1A-4B is expressed in testis. {ECO:0000269|PubMed:12062816}. |
LMX1A CRISPR/Cas9 KO Plasmid (h) - sc-418369 from Santa Cruz Biotechnology
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LMX1A HDR Plasmid (h) - sc-418369-HDR from Santa Cruz Biotechnology
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LMX1A Double Nickase Plasmid (h) - sc-418369-NIC from Santa Cruz Biotechnology
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LMX1A Double Nickase Plasmid (h2) - sc-418369-NIC-2 from Santa Cruz Biotechnology
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LMX1A CRISPR Activation Plasmid (h) - sc-418369-ACT from Santa Cruz Biotechnology
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LMX1A CRISPR Activation Plasmid (h2) - sc-418369-ACT-2 from Santa Cruz Biotechnology
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LMX1A Lentiviral Activation Particles (h) - sc-418369-LAC from Santa Cruz Biotechnology
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LMX1A Lentiviral Activation Particles (h2) - sc-418369-LAC-2 from Santa Cruz Biotechnology
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LMX1A siRNA (h) - sc-72343 from Santa Cruz Biotechnology
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LMX1A shRNA Plasmid (h) - sc-72343-SH from Santa Cruz Biotechnology
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LMX1A shRNA (h) Lentiviral Particles - sc-72343-V from Santa Cruz Biotechnology
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LMX1A RNAi - H00004009-R02 from Novus Biologicals
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LMX1A RNAi - H00004009-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN11783 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11783 from Sigma-Aldrich
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LMX1A siRNA (Human) - CRH2714 from Cohesion Biosciences
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LMX1A RNAi - H00004009-R03 from Novus Biologicals
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shRNA set against Human Lmx1a (NM_177398.3) - SHH331147 from Creative biogene
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Human LMX1A siRNA - orb263216 from Biorbyt
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LMX1A shRNA Plasmid (Human) - CHH2714 from Cohesion Biosciences
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LMX1A miRNA 3'UTR clone - MiUTR4H-TG05102 from Creative biogene
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