Gene Symbol | KCNK6 |
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Entrez Gene | 9424 |
Alt Symbol | K2p6.1, KCNK8, TOSS, TWIK-2, TWIK2 |
Species | Human |
Gene Type | protein-coding |
Description | potassium channel, two pore domain subfamily K, member 6 |
Other Description | K2P6.1 potassium channel|TWIK-originated similarity sequence|TWIK-originated sodium similarity sequence|inward rectifying potassium channel protein TWIK-2|potassium channel subfamily K member 6 |
Swissprots | Q9HB47 Q9Y257 |
Accessions | CAB70443 CAC15489 CAC39539 CAC39540 EAW56776 Q9Y257 AF117708 AAD24000 AF134149 AAD22980 AF281302 AAG10506 AF281303 AAG10507 AK022344 AK222545 BAD96265 AK315653 BAG38019 BC004367 AAH04367 DQ893422 ABM84348 DQ896740 ABM87739 EU978937 ACH86096 XM_011527526 XP_011525828 XM_011527527 XP_011525829 NM_004823 NP_004814 |
Function | Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions. |
Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Widespread expression, detected in all tissues tested except for skeletal muscle. Strongest expression in placenta, pancreas, heart, colon and spleen, lower levels detected in peripheral blood leukocytes, lung, liver, kidney and thymus. Lowest expression detected in brain. |
TWIK-2 CRISPR/Cas9 KO Plasmid (h) - sc-407263 from Santa Cruz Biotechnology
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TWIK-2 HDR Plasmid (h) - sc-407263-HDR from Santa Cruz Biotechnology
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TWIK-2 Double Nickase Plasmid (h) - sc-407263-NIC from Santa Cruz Biotechnology
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TWIK-2 Double Nickase Plasmid (h2) - sc-407263-NIC-2 from Santa Cruz Biotechnology
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TWIK-2 CRISPR Activation Plasmid (h) - sc-407263-ACT from Santa Cruz Biotechnology
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TWIK-2 CRISPR Activation Plasmid (h2) - sc-407263-ACT-2 from Santa Cruz Biotechnology
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TWIK-2 Lentiviral Activation Particles (h) - sc-407263-LAC from Santa Cruz Biotechnology
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TWIK-2 Lentiviral Activation Particles (h2) - sc-407263-LAC-2 from Santa Cruz Biotechnology
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TWIK-2 siRNA (h) - sc-42351 from Santa Cruz Biotechnology
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TWIK-2 shRNA Plasmid (h) - sc-42351-SH from Santa Cruz Biotechnology
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TWIK-2 shRNA (h) Lentiviral Particles - sc-42351-V from Santa Cruz Biotechnology
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Potassium channel subfamily K member 6 RNAi - H00009424-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN10974 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10974 from Sigma-Aldrich
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KCNK6 siRNA (Human) - CRH6250 from Cohesion Biosciences
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shRNA set against Human KCNK6 (NM_004823.1) - SHH323495 from Creative biogene
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shRNA set against Human KCNK6(NM_004823.1) - SHL190416 from Creative biogene
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Human KCNK6 siRNA - orb266752 from Biorbyt
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KCNK6 shRNA Plasmid (Human) - CHH6250 from Cohesion Biosciences
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KCNK6 miRNA 3'UTR clone - MiUTR1H-05149 from Creative biogene
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