Gene Symbol | JMJD7-PLA2G4B |
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Entrez Gene | 8681 |
Alt Symbol | HsT16992, cPLA2-beta |
Species | Human |
Gene Type | protein-coding |
Description | JMJD7-PLA2G4B readthrough |
Other Description | JMJD7-PLA2G4B protein|jumonji domain containing 7-phospholipase A2, group IVB (cytosolic) read-through |
Swissprots | P0C869 B4DRT9 Q19KD5 Q19KD6 |
Accessions | EAW92521 AA064721 AB209150 BAD92387 AF065215 AAC78836 AF065216 AF121908 AAD32135 BC013415 BC128426 BC172355 AAI72355 BI768993 BU688449 DA080158 DA096882 DA121536 DQ523799 ABF69195 DQ523800 ABF69196 NM_001198588 NP_001185517 NM_005090 NP_005081 NR_015346 |
Function | Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A. Isoform 3 has calcium-dependent activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine. Isoform 5 does have activity against phosphatidylcholine. {ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:16617059}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:16617059}. |
Tissue Specificity | Widely expressed. Expressed at higher level in brain, heart, liver, cerebellum and pancreas. Isoform 3 is widely expressed. {ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:16617059}. |
Top Pathways | Long-term depression, Choline metabolism in cancer, Oxytocin signaling pathway, VEGF signaling pathway, Inflammatory mediator regulation of TRP channels |
JMJD7 (11K2) - sc-134351 from Santa Cruz Biotechnology
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group IVB sPLA 2 (S-19) - sc-162906 from Santa Cruz Biotechnology
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group IVB sPLA 2 (T-15) - sc-162907 from Santa Cruz Biotechnology
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PLA2G4B Antibody - NBP1-80112 from Novus Biologicals
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PLA2G4B Antibody - NBP1-80305 from Novus Biologicals
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CPLA2 beta Polyclonal Antibody - bs-3780R from Bioss
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Monoclonal Anti-PLA2G4B antibody produced in mouse - WH0008681M1 from Sigma-Aldrich
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Anti-PLA2G4B (ab1) antibody produced in rabbit - SAB2101821 from Sigma-Aldrich
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Anti-PLA2G4B (ab2) antibody produced in rabbit - SAB2101822 from Sigma-Aldrich
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Anti-PLA2G4B antibody produced in rabbit - SAB1411553 from Sigma-Aldrich
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PLA2G4B antibody - N-terminal region (ARP35757_P050) - ARP35757_P050 from Aviva Systems Biology
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PLA2G4B antibody - N-terminal region (ARP38556_P050) - ARP38556_P050 from Aviva Systems Biology
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PA24B Antibody - C-terminal region (ARP38557_P050) - ARP38557_P050 from Aviva Systems Biology
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CPLA2 beta Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-3780R-A350 from Bioss
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CPLA2 beta Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-3780R-A488 from Bioss
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CPLA2 beta Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-3780R-A555 from Bioss
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CPLA2 beta Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-3780R-A647 from Bioss
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CPLA2 beta Polyclonal Antibody, Cy3 Conjugated - bs-3780R-Cy3 from Bioss
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CPLA2 beta Polyclonal Antibody, Cy5 Conjugated - bs-3780R-Cy5 from Bioss
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CPLA2 beta Polyclonal Antibody, Cy5.5 Conjugated - bs-3780R-Cy5.5 from Bioss
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CPLA2 beta Polyclonal Antibody, Cy7 Conjugated - bs-3780R-Cy7 from Bioss
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CPLA2 beta Polyclonal Antibody, FITC Conjugated - bs-3780R-FITC from Bioss
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CPLA2 beta Polyclonal Antibody, Biotin Conjugated - bs-3780R-Biotin from Bioss
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CPLA2 beta Polyclonal Antibody, HRP Conjugated - bs-3780R-HRP from Bioss
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PLA2G4B antibody - H00008681-B01 from Acris Antibodies
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