| Gene Symbol |
JMJD7-PLA2G4B
|
| Entrez Gene |
8681
|
| Alt Symbol |
HsT16992, cPLA2-beta
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
JMJD7-PLA2G4B readthrough
|
| Other Description |
JMJD7-PLA2G4B protein|jumonji domain containing 7-phospholipase A2, group IVB (cytosolic) read-through
|
| Swissprots |
P0C869 B4DRT9 Q19KD5 Q19KD6
|
| Accessions |
EAW92521 AA064721 AB209150 BAD92387 AF065215 AAC78836 AF065216 AF121908 AAD32135 BC013415 BC128426 BC172355 AAI72355 BI768993 BU688449 DA080158 DA096882 DA121536 DQ523799 ABF69195 DQ523800 ABF69196 NM_001198588 NP_001185517 NM_005090 NP_005081 NR_015346
|
| Function |
Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A. Isoform 3 has calcium-dependent activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine. Isoform 5 does have activity against phosphatidylcholine. {ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:16617059}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:16617059}.
|
| Tissue Specificity |
Widely expressed. Expressed at higher level in brain, heart, liver, cerebellum and pancreas. Isoform 3 is widely expressed. {ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:16617059}.
|
| Top Pathways |
Long-term depression, Choline metabolism in cancer, Oxytocin signaling pathway, VEGF signaling pathway, Inflammatory mediator regulation of TRP channels
|
