| Gene Symbol |
UGT2B15
|
| Entrez Gene |
7366
|
| Alt Symbol |
HLUG4, UDPGT 2B8, UDPGT2B15, UDPGTH3, UGT2B8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
UDP glucuronosyltransferase 2 family, polypeptide B15
|
| Other Description |
UDP glycosyltransferase 2B15|UDP-glucuronosyltransferase 2B15|UDP-glucuronosyltransferase 2B8|UDP-glucuronosyltransferase UGT2B15|UDP-glucuronyltransferase, family 2, beta-15|UDPGT 2B15|UDPGTh-3
|
| Swissprots |
A6NNJ4 Q9UK63 P54855 A8K054 P23765 A6NDX0
|
| Accessions |
AAB28536 AAF25010 EAX05574 P54855 AF180322 AAD55093 AF548389 AAN40695 AK289419 BAF82108 BC141423 AAI41424 BC146570 AAI46571 BC171879 AAI71879 U06641 AAA83406 U08854 AAC50077 NM_001076 NP_001067
|
| Function |
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens.
|
| Subcellular Location |
Microsome membrane {ECO:0000305}; Single- pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed in many tissues. Present in liver, prostate and testis. {ECO:0000269|PubMed:8399210}.
|
| Top Pathways |
Chemical carcinogenesis, Steroid hormone biosynthesis, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450
|