Gene Symbol | UGT2B15 |
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Entrez Gene | 7366 |
Alt Symbol | HLUG4, UDPGT 2B8, UDPGT2B15, UDPGTH3, UGT2B8 |
Species | Human |
Gene Type | protein-coding |
Description | UDP glucuronosyltransferase 2 family, polypeptide B15 |
Other Description | UDP glycosyltransferase 2B15|UDP-glucuronosyltransferase 2B15|UDP-glucuronosyltransferase 2B8|UDP-glucuronosyltransferase UGT2B15|UDP-glucuronyltransferase, family 2, beta-15|UDPGT 2B15|UDPGTh-3 |
Swissprots | A6NNJ4 Q9UK63 P54855 A8K054 P23765 A6NDX0 |
Accessions | AAB28536 AAF25010 EAX05574 P54855 AF180322 AAD55093 AF548389 AAN40695 AK289419 BAF82108 BC141423 AAI41424 BC146570 AAI46571 BC171879 AAI71879 U06641 AAA83406 U08854 AAC50077 NM_001076 NP_001067 |
Function | UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens. |
Subcellular Location | Microsome membrane {ECO:0000305}; Single- pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Expressed in many tissues. Present in liver, prostate and testis. {ECO:0000269|PubMed:8399210}. |
Top Pathways | Chemical carcinogenesis, Steroid hormone biosynthesis, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450 |
UGT2B15 CRISPR/Cas9 KO Plasmid (h) - sc-405610 from Santa Cruz Biotechnology
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UGT2B15 HDR Plasmid (h) - sc-405610-HDR from Santa Cruz Biotechnology
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UGT2B15 Double Nickase Plasmid (h) - sc-405610-NIC from Santa Cruz Biotechnology
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UGT2B15 Double Nickase Plasmid (h2) - sc-405610-NIC-2 from Santa Cruz Biotechnology
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UGT2B15 CRISPR Activation Plasmid (h) - sc-405610-ACT from Santa Cruz Biotechnology
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UGT2B15 CRISPR Activation Plasmid (h2) - sc-405610-ACT-2 from Santa Cruz Biotechnology
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UGT2B15 Lentiviral Activation Particles (h) - sc-405610-LAC from Santa Cruz Biotechnology
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UGT2B15 Lentiviral Activation Particles (h2) - sc-405610-LAC-2 from Santa Cruz Biotechnology
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UGT2B15 siRNA (h) - sc-89282 from Santa Cruz Biotechnology
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UGT2B15 shRNA Plasmid (h) - sc-89282-SH from Santa Cruz Biotechnology
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UGT2B15 shRNA (h) Lentiviral Particles - sc-89282-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN22469 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22469 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04516 from Sigma-Aldrich
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UGT2B15 siRNA (Human) - CRH5037 from Cohesion Biosciences
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UGT2B15 - MBS8213637 from MyBioSource
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UGT2B15 CRISPR/Cas9 KO Plasmid (h2) - sc-405610-KO-2 from Santa Cruz Biotechnology
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UGT2B15 HDR Plasmid (h2) - sc-405610-HDR-2 from Santa Cruz Biotechnology
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Human UGT2B15 siRNA - orb265539 from Biorbyt
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UGT2B15 shRNA Plasmid (Human) - CHH5037 from Cohesion Biosciences
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UGT2B15 miRNA 3'UTR clone - MiUTR3H-03123 from Creative biogene
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