Gene Symbol | UGT2B15 |
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Entrez Gene | 7366 |
Alt Symbol | HLUG4, UDPGT 2B8, UDPGT2B15, UDPGTH3, UGT2B8 |
Species | Human |
Gene Type | protein-coding |
Description | UDP glucuronosyltransferase 2 family, polypeptide B15 |
Other Description | UDP glycosyltransferase 2B15|UDP-glucuronosyltransferase 2B15|UDP-glucuronosyltransferase 2B8|UDP-glucuronosyltransferase UGT2B15|UDP-glucuronyltransferase, family 2, beta-15|UDPGT 2B15|UDPGTh-3 |
Swissprots | A6NNJ4 Q9UK63 P54855 A8K054 P23765 A6NDX0 |
Accessions | AAB28536 AAF25010 EAX05574 P54855 AF180322 AAD55093 AF548389 AAN40695 AK289419 BAF82108 BC141423 AAI41424 BC146570 AAI46571 BC171879 AAI71879 U06641 AAA83406 U08854 AAC50077 NM_001076 NP_001067 |
Function | UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens. |
Subcellular Location | Microsome membrane {ECO:0000305}; Single- pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Expressed in many tissues. Present in liver, prostate and testis. {ECO:0000269|PubMed:8399210}. |
Top Pathways | Chemical carcinogenesis, Steroid hormone biosynthesis, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450 |
Anti-UGT2B15 antibody - ab170750 from Abcam
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Anti-UGT2B15 antibody - ab89274 from Abcam
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Anti-UGT2B15 antibody - ab83468 from Abcam
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Anti-UGT2B15 antibody [EPR10615(B)] - ab154864 from Abcam
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Anti-UGT2B15 Antibody (aa156-185) - LS-C160420 from LifeSpan Bioscience
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Anti-UGT2B15 Antibody (aa156-185, AP) - LS-C273010 from LifeSpan Bioscience
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Anti-UGT2B15 Antibody (aa156-185, FITC) - LS-C273013 from LifeSpan Bioscience
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Anti-UGT2B15 Antibody (aa156-185, APC) - LS-C273011 from LifeSpan Bioscience
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Anti-UGT2B15 Antibody (aa156-185, Biotin) - LS-C273012 from LifeSpan Bioscience
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Anti-UGT2B15 Antibody (aa156-185, Azide-free, HRP) - LS-C273014 from LifeSpan Bioscience
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Anti-UGT2B15 Antibody (aa163-193) - LS-C326174 from LifeSpan Bioscience
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Anti-UGT2B15 Antibody (aa156-185, PE) - LS-C273016 from LifeSpan Bioscience
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Anti-UGT2B15 Antibody (aa72-121) - LS-C101936 from LifeSpan Bioscience
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UGT2B15 Antibody - H00007366-B01P from Novus Biologicals
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UGT2B15 Antibody - H00007366-D01P from Novus Biologicals
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UGT2B15 Antibody - NBP1-69700 from Novus Biologicals
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UGT2B15 Antibody - H00007366-D01 from Novus Biologicals
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Anti-UGT2B15 antibody produced in rabbit - SAB2102644 from Sigma-Aldrich
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Anti-UGT2B15 antibody produced in rabbit - SAB1411383 from Sigma-Aldrich
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Anti-UGT2B15 antibody produced in mouse - SAB1400295 from Sigma-Aldrich
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UGT2B15 antibody - N-terminal region (ARP41906_P050) - ARP41906_P050 from Aviva Systems Biology
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UGT2B15-Antibody-Center - AP12375c from Abgent, a WuXi AppTec company
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UGT2B15 Antibody - middle region (OAAB08639) - OAAB08639 from Aviva Systems Biology
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UGT2B15 antibody - 70R-7532 from Fitzgerald
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UGT2B15 / UGT2B8 (Center) antibody - AP54455PU-N from Acris Antibodies
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