| Gene Symbol |
SLAMF1
|
| Entrez Gene |
6504
|
| Alt Symbol |
CD150, CDw150, SLAM
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
signaling lymphocytic activation molecule family member 1
|
| Other Description |
IPO-3|signaling lymphocytic activation molecule
|
| Swissprots |
Q13291 Q9HBE8 Q5W172
|
| Accessions |
AAG10433 AAG10434 AAG17628 CAR96687 CAR96689 EAW52706 Q13291 AA825199 AK304237 BAG65106 AK311666 AK314244 BAG36911 AY040554 AAK77968 BC012602 AAH12602 BC067847 BC110349 BC132792 AAI32793 BC144498 BC144499 BC144500 DB133023 HQ258195 ADR82949 KF471075 AHF72732 U33017 AAA75380 XM_005245456 XP_005245513 XM_005245457 XP_005245514 XM_011509905 XP_011508207 NM_003037 NP_003028 NR_104399 NR_104400 NR_104401
|
| Function |
High-affinity self-ligand important in bidirectional T- cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein. Note=Present on the surface of B-cells and T-cells.
|
| Tissue Specificity |
Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation.
|
| Top Pathways |
Measles
|
