PLEKHG6

Gene Symbol PLEKHG6
Entrez Gene 55200
Alt Symbol MyoGEF
Species Human
Gene Type protein-coding
Description pleckstrin homology domain containing, family G (with RhoGef domain) member 6
Other Description PH domain-containing family G member 6|myosin II interacting GEF|myosin interacting guanine nucleotide exchange factor|myosin-interacting guanine nucleotide exchange factor|pleckstrin homology domain-containing family G member 6
Swissprots Q8WYY1 Q3SWR1 Q8N1P1 Q9NVK9 Q9H8F4 Q3KR16
Accessions EAW88807 EAW88808 EAW88809 EAW88810 Q3KR16 AF289613 AAL55797 AK001527 BAA91741 AK023741 AK095373 BAC04539 AW001611 BC040273 BC104751 AAI04752 BC105961 AAI05962 BC109095 AAI09096 BU754580 XM_005253704 XP_005253761 XM_006718985 XP_006719048 XM_011520967 XP_011519269 XR_931514 NM_001144856 NP_001138328 NM_001144857 NP_001138329 NM_018173 NP_060643
Function Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. {ECO:0000269|PubMed:16721066, ECO:0000269|PubMed:17881735}.
Subcellular Location Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cleavage furrow. Note=During mitosis, localizes to the spindle pole, central spindle and cleavage furrow. In epithelial cells, recruited to the apical membrane by EZR.
Tissue Specificity Highest expression in the placenta. Low levels in small intestine, lung, liver, kidney, thymus and heart.

PLEKHG6 (C-18) - sc-243824 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-MyoGEF antibody - ab140116 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MyoGEF antibody (ab140116) at 1/1000 dilutionLane 1 : Human fetal intestine lysateLane 2 : Human fetal kidney lysate

Anti-MyoGEF antibody - ab91412 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-MyoGEF antibody (ab91412) at 1/100 dilution + NCI-H460 cell lysate at 35 µg

Anti-PLEKHG6 Antibody (N-Terminus, AP) - LS-C225933 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLEKHG6 Antibody (N-Terminus, Biotin) - LS-C225934 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLEKHG6 Antibody (N-Terminus, APC) - LS-C225935 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLEKHG6 Antibody (N-Terminus, FITC) - LS-C225936 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLEKHG6 Antibody (N-Terminus, Azide-free, HRP) - LS-C225937 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLEKHG6 Antibody (N-Terminus, PE) - LS-C225939 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLEKHG6 Antibody (N-Terminus, Azide-free) - LS-C327966 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLEKHG6 Antibody (aa196-453) - LS-C179072 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PLEKHG6 Antibody (aa60-87) - LS-C164723 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human lung carcinoma with MyoGEF Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

PLEKHG6 Antibody - NBP1-83840 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PLEKHG6 Antibody [NBP1-83840] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp. Lane 4: Human plasma (IgG/HSA depleted). Lane 5: Human liver tissue. Lane 6: Human tonsil tissue

MyoGEF Polyclonal Antibody - bs-7756R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ANTI-MYOGEF (N-TERM) antibody produced in rabbit - SAB1303017 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>MyoGEF (N-term): <B>Cat. No. SAB1303017</B>: MyoGEF in Human lung carcinoma tissue with MyoGEF antibody (N-term) at 5 μg/mL.

Anti-PLEKHG6 antibody produced in rabbit - HPA041459 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PLEKHG6: <B>Cat. No. HPA041459</B>: Immunohistochemical staining of human placenta shows strong membranous staining positivity in trophoblastic cells.

MyoGEF-Antibody-N-term - AP6922a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of MyoGEF Antibody (N-term) (Cat. #AP6922a) in NCI-H460 cell line lysates (35ug/lane). MyoGEF (arrow) was detected using the purified Pab.

PLEKHG6 Antibody - N-terminal region (OAAB04037) - OAAB04037 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

MyoGEF antibody, N-term - GTX81649 from GeneTex

Prices $319.00
Sizes 400 μl
Host Rabbit
Clonality Polyclonal
Anti-MyoGEF antibody, N-term used in Flow cytometry/FACS. GTX81649

PLEKHG6 antibody - orb78376 from Biorbyt

Prices $425.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed paraffin embedded placenta showing cytoplasmic staining using PLEKHG6 antibody

PLEKHG6 antibody - 70R-35711 from Fitzgerald

Host Rabbit
Clonality Polyclonal

MyoGEF Antibody - abx033067 from Abbexa

Host Rabbit
Clonality Polyclonal

PLEKHG6 Antibody - abx037123 from Abbexa

Host Rabbit
Clonality Polyclonal

MyoGEF (N-term) antibody - AP17576PU-N from Acris Antibodies

Prices $330.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of MyoGEF Antibody (N-term) (AP17576PU-N) in NCI-H460 cell line lysates (35ug/lane). MyoGEF (arrow) was detected using the purified Pab.

Rabbit Anti-Human MyoGEF (N-term) - 102-17017 from RayBiotech

Host Rabbit
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