| Gene Symbol |
PLEKHG6
|
| Entrez Gene |
55200
|
| Alt Symbol |
MyoGEF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
|
| Other Description |
PH domain-containing family G member 6|myosin II interacting GEF|myosin interacting guanine nucleotide exchange factor|myosin-interacting guanine nucleotide exchange factor|pleckstrin homology domain-containing family G member 6
|
| Swissprots |
Q8WYY1 Q3SWR1 Q8N1P1 Q9NVK9 Q9H8F4 Q3KR16
|
| Accessions |
EAW88807 EAW88808 EAW88809 EAW88810 Q3KR16 AF289613 AAL55797 AK001527 BAA91741 AK023741 AK095373 BAC04539 AW001611 BC040273 BC104751 AAI04752 BC105961 AAI05962 BC109095 AAI09096 BU754580 XM_005253704 XP_005253761 XM_006718985 XP_006719048 XM_011520967 XP_011519269 XR_931514 NM_001144856 NP_001138328 NM_001144857 NP_001138329 NM_018173 NP_060643
|
| Function |
Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. {ECO:0000269|PubMed:16721066, ECO:0000269|PubMed:17881735}.
|
| Subcellular Location |
Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cleavage furrow. Note=During mitosis, localizes to the spindle pole, central spindle and cleavage furrow. In epithelial cells, recruited to the apical membrane by EZR.
|
| Tissue Specificity |
Highest expression in the placenta. Low levels in small intestine, lung, liver, kidney, thymus and heart.
|