PLEKHG6

Gene Symbol PLEKHG6
Entrez Gene 55200
Alt Symbol MyoGEF
Species Human
Gene Type protein-coding
Description pleckstrin homology domain containing, family G (with RhoGef domain) member 6
Other Description PH domain-containing family G member 6|myosin II interacting GEF|myosin interacting guanine nucleotide exchange factor|myosin-interacting guanine nucleotide exchange factor|pleckstrin homology domain-containing family G member 6
Swissprots Q8WYY1 Q3SWR1 Q8N1P1 Q9NVK9 Q9H8F4 Q3KR16
Accessions EAW88807 EAW88808 EAW88809 EAW88810 Q3KR16 AF289613 AAL55797 AK001527 BAA91741 AK023741 AK095373 BAC04539 AW001611 BC040273 BC104751 AAI04752 BC105961 AAI05962 BC109095 AAI09096 BU754580 XM_005253704 XP_005253761 XM_006718985 XP_006719048 XM_011520967 XP_011519269 XR_931514 NM_001144856 NP_001138328 NM_001144857 NP_001138329 NM_018173 NP_060643
Function Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. {ECO:0000269|PubMed:16721066, ECO:0000269|PubMed:17881735}.
Subcellular Location Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cleavage furrow. Note=During mitosis, localizes to the spindle pole, central spindle and cleavage furrow. In epithelial cells, recruited to the apical membrane by EZR.
Tissue Specificity Highest expression in the placenta. Low levels in small intestine, lung, liver, kidney, thymus and heart.

Human MyoGEF protein fragment - ab127271 from Abcam

Category Protein
Source E. coli
Species Human

PLEKHG6 Antibody Blocking Peptide - LS-E8549 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

PLEKHG6 Recombinant Protein - H00055200-P01 from Novus Biologicals

Category Protein
Species Human

MyoGEF-Antibody-N-term-Blocking-Peptide - BP6922a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

MyoGEF - H00055200-P01 from Acris Antibodies

Category Protein
Prices $340.00
Sizes 2 µg
Species Human

PLEKHG6 fusion protein - Ag16575 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

PLEKHG6 fusion protein - ag15886 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human PLEKHG6, His-tagged - PLEKHG6-1784H from Creative Biomart

Category Protein
Source E.coli
Species Human

Recombinant Human Pleckstrin homology domain-containing family G member 6(PLEKHG - CSB-YP664666HU CSB-EP664666HU CSB-BP664666HU CSB-MP664666HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

MyoGEF (transcript variant 3) - TP327365 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
MyoGEF

Pleckstrin homology domain-containing family G member 6 (PLEKHG6), Recombinant Protein - MBS1313639 from MyBioSource

Category Protein
Prices $1,610.00, $1,610.00, $1,840.00, $1,840.00, $2,765.00, $2,765.00, $3,225.00, $3,225.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

PLEKHG6 Recombinant Protein Antigen - NBP1-83840PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

PLEKHG6 Peptide, Human - M34GP11940H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

PLEKHG6 Recombinant Protein Antigen - NBP2-55380PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human
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