Gene Symbol | ADIPOQ |
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Entrez Gene | 9370 |
Alt Symbol | ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, APM1, GBP28 |
Species | Human |
Gene Type | protein-coding |
Description | adiponectin, C1Q and collagen domain containing |
Other Description | 30 kDa adipocyte complement-related protein|adipocyte complement-related 30 kDa protein|adiponectin|adipose most abundant gene transcript 1 protein|adipose specific collagen-like factor|gelatin-binding protein 28 |
Swissprots | Q58EX9 Q15848 |
Accessions | BAA86716 CAB52413 CAT82843 CBL63519 EAW78165 Q15848 AK291525 BAF84214 AK312868 BAG35720 AL832470 AX767959 CAE01099 BC054496 AAH54496 BC096308 AAH96308 BC096309 AAH96309 BC096310 AAH96310 BC096311 AAH96311 D45371 BAA08227 EU420013 ABZ10942 XM_011513324 XP_011511626 NM_001177800 NP_001171271 NM_004797 NP_004788 |
Function | Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. {ECO:0000269|PubMed:11479627}. |
Subcellular Location | Secreted. |
Tissue Specificity | Synthesized exclusively by adipocytes and secreted into plasma. |
Top Pathways | Adipocytokine signaling pathway, Type II diabetes mellitus, PPAR signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AMPK signaling pathway |
ADIPOQ-Over-expression-Lysate - LY12086a from Abgent, a WuXi AppTec company
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ADIPOQ 293 Cell Lysate - 401367 from ABBIOTEC
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Adiponectin/Acrp30 Overexpression Lysate (Native) - NBL1-07342 from Novus Biologicals
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ADIPOQ Over-expression Lysate Product - GWB-8D1E13 from Genway Biotech
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Human Adiponectin / Acrp30 / ADIPOQ HEK293 Cell Lysate (WB positive control) - 10772-H02HL-300 from Sino Biological
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Human Adiponectin (ACRP30) Deficient Plasma (EDTA) - D250004 from AssayPro
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Human Adiponectin (ACRP30) Deficient Plasma (EDTA) - D250005 from AssayPro
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Human Adiponectin (ACRP30) Deficient Plasma (EDTA) - D250006 from AssayPro
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Human Adiponectin (ACRP30) Deficient Plasma (Heparin) - D250007 from AssayPro
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Human Adiponectin (ACRP30) Deficient Plasma (Heparin) - D250008 from AssayPro
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Human Adiponectin (ACRP30) Deficient Plasma (Heparin) - D250009 from AssayPro
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Human Adiponectin (ACRP30) Deficient Plasma (Sodium Citrate) - D250002 from AssayPro
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Human Adiponectin (ACRP30) Deficient Plasma (Sodium Citrate) - D250003 from AssayPro
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Human Adiponectin (ACRP30) Deficient Plasma (Sodium Citrate) - D250001 from AssayPro
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Human Adiponectin (ACRP30) Deficient Serum - D250010 from AssayPro
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Human Adiponectin (ACRP30) Deficient Serum - D250011 from AssayPro
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Human Adiponectin (ACRP30) Deficient Serum - D250012 from AssayPro
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Human Adiponectin Human Cells Transfected Lysate (positive control) (denatured) - orb174156 from Biorbyt
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Panoply™ Human ADIPOQ Knockdown Stable Cell Line - CSC-DC000308 from Creative biogene
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