ADIPOQ

Gene Symbol ADIPOQ
Entrez Gene 9370
Alt Symbol ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, APM1, GBP28
Species Human
Gene Type protein-coding
Description adiponectin, C1Q and collagen domain containing
Other Description 30 kDa adipocyte complement-related protein|adipocyte complement-related 30 kDa protein|adiponectin|adipose most abundant gene transcript 1 protein|adipose specific collagen-like factor|gelatin-binding protein 28
Swissprots Q58EX9 Q15848
Accessions BAA86716 CAB52413 CAT82843 CBL63519 EAW78165 Q15848 AK291525 BAF84214 AK312868 BAG35720 AL832470 AX767959 CAE01099 BC054496 AAH54496 BC096308 AAH96308 BC096309 AAH96309 BC096310 AAH96310 BC096311 AAH96311 D45371 BAA08227 EU420013 ABZ10942 XM_011513324 XP_011511626 NM_001177800 NP_001171271 NM_004797 NP_004788
Function Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. {ECO:0000269|PubMed:11479627}.
Subcellular Location Secreted.
Tissue Specificity Synthesized exclusively by adipocytes and secreted into plasma.
Top Pathways Adipocytokine signaling pathway, Type II diabetes mellitus, PPAR signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AMPK signaling pathway

Adiponectin (C45B10) Rabbit mAb - 2789 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C45B10
Western blot analysis of extracts from NIH/3T3 and 3T3-L1 cells using Adiponectin (C45B10) Rabbit mAb.

Acrp30 (A-13) - sc-26497 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Acrp30 (A-13): sc-26497. Immunofluorescence staining of methanol-fixed MIA PaCa-2 cells showing cytoplasmic localization.

Acrp30 (G-17) - sc-26496 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Acrp30 (G-17): sc-26496. Immunofluorescence staining of methanol-fixed Mia PaCa-2 cells showing cytoplasmic localization.

Acrp30 (31) - sc-136131 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Acrp30 (31): sc-136131. Western blot analysis of Acrp30 protein purified from human plasma.

Anti-Adiponectin antibody - ab62551 from Abcam

Prices $382.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-Adiponectin antibody (ab62551) at 1 µg/mlLane 2 : Anti-Adiponectin antibody (ab62551) at 2 µg/mlLane 3 : Anti-Adiponectin antibody (ab62551) at 4 µg/mlLane 1 : Rat brain cell lysateLane 2 : Rat brain cell lysateLane 3 : Rat brain cell lysateLysates/proteins at 15 µg per lane.

Anti-Adiponectin antibody - ab25891 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-Adiponectin antibody (ab25891) at 0.5 µg/mlLane 2 : Anti-Adiponectin antibody (ab25891) at 1 µg/mlLane 3 : Anti-Adiponectin antibody (ab25891) at 2 µg/mlLane 1 : HL60 cell lysateLane 2 : HL60 cell lysateLane 3 : HL60 cell lysate

Anti-Adiponectin antibody - ab18839 from Abcam

Prices $372.00
Sizes 125 µg
Host Rabbit
Clonality Polyclonal

Anti-Adiponectin antibody - ab99255 from Abcam

Prices $376.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
IHC image of 99255 staining in Human Breast Adipose formalin fixed paraffin embedded tissue section, performed on a Leica Bond system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab99255, 10µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

Anti-Adiponectin antibody - ab18851 from Abcam

Prices $370.00
Sizes 125 µg
Host Rabbit
Clonality Polyclonal

Anti-Adiponectin antibody - ab13881 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-Adiponectin antibody - ab18065 from Abcam

Prices $372.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-Adiponectin antibody - ab32003 from Abcam

Host Chicken
Clonality Polyclonal
Anti-Adiponectin antibody (ab32003) at 1/3000 dilution (in 1% milk in PBS T at room temperature for 1 hour) + Adiponectin fusion protein (400ng)Secondarygoat anti IgY/Fc HRP at 1/10000 dilutiondeveloped using the ECL technique

Anti-Adiponectin antibody - ab134692 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Adiponectin antibody (ab134692) at 1/500 dilution + HeLa cell extract at 30 µg

Anti-Adiponectin antibody - ab26048 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-Adiponectin antibody - ab167005 from Abcam

Host Goat
Clonality Polyclonal

Anti-Adiponectin antibody [1.3-13A05-2D09] - ab131148 from Abcam

Prices $370.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
Clone 1.3-13A05-2D09

Anti-Adiponectin antibody [19F1] - ab22554 from Abcam

Prices $400.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 19F1
ab22554 staining Adiponectin in 3T3-L1 cells (ATCC® CL-173 TM). Increased expression of Adiponectin correlates with adipocyte phenotype, as described in literature. Cells, grown to confluency in DMEM with 10% FBS, were differentiated by stimulation for two days with 0.5 mM 3-isobutyl-1-methylxanthi​ne (ab120840), 0.25uM dexamethasone (ab120743) and 1ug/ml insulin (ab123768), followed by two more days with only insulin. Cells were maintained for an additional three days in growth medium alone. Undifferentiated and differentiated adipocytes were fixed with 100% methanol (5min) at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 1h at room temperature. Staining of the treated cells with ab22554 (2.5µg/ml) and ab6046 at 1µg/ml overnight at +4°C, was followed by a further incubation at room temperature for 1h with an AlexaFluor®488 Goat anti-Rabbit secondary (ab150081) at 2 µg/ml (shown in green) and AlexaFluor®594 Goat anti-Mouse sec

Anti-Adiponectin antibody [1B2] - ab113943 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1B2
All lanes : Anti-Adiponectin antibody [1B2] (ab113943) at 1/500 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control cDNA Lane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY Adiponectin cDNA Lysates/proteins at 5 µg per lane.

Anti-Adiponectin antibody [B014M] - ab130879 from Abcam

Prices $370.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal
Clone B014M

Anti-Adiponectin antibody [B478M] - ab183138 from Abcam

Prices $368.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal
Clone B478M

Anti-Adiponectin antibody [B859M] - ab131232 from Abcam

Prices $370.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal
Clone B859M

Anti-Adiponectin antibody [B863M] - ab131226 from Abcam

Prices $370.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal
Clone B863M

Anti-Adiponectin antibody [B871M] - ab183139 from Abcam

Prices $368.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal
Clone B871M

Anti-Adiponectin antibody [B872M] - ab131228 from Abcam

Prices $370.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal
Clone B872M

Anti-Adiponectin antibody (Biotin) - ab51420 from Abcam

Prices $370.00
Sizes 150 µg
Host Rabbit
Clonality Polyclonal
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