FXN

Gene Symbol	FXN
Entrez Gene	2395
Alt Symbol	CyaY, FA, FARR, FRDA, X25
Species	Human
Gene Type	protein-coding
Description	frataxin
Other Description	Friedreich ataxia protein|frataxin, mitochondrial
Swissprots	Q15294 O15545 C9JJ89 Q5VZ01 A8MXJ6 O95656 Q16595
Accessions	AAA98508 AAA98509 AAB84047 AAD00734 AAD00735 AAD00736 AAD49778 CAA74077 EAW62473 EAW62474 Q16595 AA232366 AI951739 AK308620 BC023633 AAH23633 BC048097 AAH48097 BF058880 HQ447980 ADQ32463 U43747 AAA98510 NM_000144 NP_000135 NM_001161706 NP_001155178 NM_181425 NP_852090
Function	Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. Modulates the RNA-binding activity of ACO1. {ECO:0000269|PubMed:12785837, ECO:0000269|PubMed:15247478, ECO:0000269|PubMed:15641778, ECO:0000269|PubMed:16239244, ECO:0000269|PubMed:16608849, ECO:0000269|PubMed:20053667}.
Subcellular Location	Cytoplasm. Mitochondrion. Note=PubMed:18725397 reports localization exclusively in mitochondria.
Tissue Specificity	Expressed in the heart, peripheral blood lymphocytes and dermal fibroblasts. {ECO:0000269|PubMed:17468497}.
Top Pathways	Porphyrin and chlorophyll metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Recombinant Frataxin (human) - ab110353 from Abcam Source E. coli Species Human

Human Frataxin full length protein - ab95502 from Abcam Category Protein Source E. coli Species Human

Human Frataxin peptide - ab48280 from Abcam Category Peptide

Recombinant Frataxin (mouse) - ab195175 from Abcam Source E. coli Species Mouse

FXN / Frataxin Antibody Blocking Peptide - LS-E8230 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FXN / Frataxin Antibody Blocking Peptide - LS-E8229 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FXN / Frataxin Antibody Blocking Peptide - LS-E18435 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FXN / Frataxin Antibody Blocking Peptide - LS-E17360 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Frataxin Protein - H00002395-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Frataxin Protein - H00002395-Q01 from Novus Biologicals Category Protein Prices $529.00 Sizes 25 µg Source Wheat Germ Species Human

Recombinant Human Frataxin Protein - NBP1-30312 from Novus Biologicals Category Protein Prices $369.00 Sizes 100 µg Source E.coli Species Human

Frataxin Peptide - P2054 from Novus Biologicals Category Peptide Species Human

Frataxin Peptide - P2055 from Novus Biologicals Category Peptide Species Human

FXN-Antibody-Center-Blocking-Peptide - BP6409c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FXN-Antibody-C-term-Blocking-Peptide - BP6409b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Frataxin Protein (OPPA01952) - OPPA01952 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human Frataxin protein - orb81126 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Species Human

Frataxin protein (His tag) - 80R-1235 from Fitzgerald Category Protein Prices $340.00 Sizes 100 µg Source E.coli

Fxn Blocking Peptide - 33R-9164 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Frataxin (FXN) (42-210, His-tag) - AR09331PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 500 µg Source E. coli Species Human

Frataxin (FXN) (42-210, His-tag) - AR09331PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 100 µg Source E. coli Species Human

Frataxin (FXN) - H00002395-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Frataxin (FXN) - H00002395-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Frataxin (FXN) - H00002395-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Frataxin (FXN) - H00002395-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

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