FXN

Gene Symbol	FXN
Entrez Gene	2395
Alt Symbol	CyaY, FA, FARR, FRDA, X25
Species	Human
Gene Type	protein-coding
Description	frataxin
Other Description	Friedreich ataxia protein|frataxin, mitochondrial
Swissprots	Q15294 O15545 C9JJ89 Q5VZ01 A8MXJ6 O95656 Q16595
Accessions	AAA98508 AAA98509 AAB84047 AAD00734 AAD00735 AAD00736 AAD49778 CAA74077 EAW62473 EAW62474 Q16595 AA232366 AI951739 AK308620 BC023633 AAH23633 BC048097 AAH48097 BF058880 HQ447980 ADQ32463 U43747 AAA98510 NM_000144 NP_000135 NM_001161706 NP_001155178 NM_181425 NP_852090
Function	Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. Modulates the RNA-binding activity of ACO1. {ECO:0000269|PubMed:12785837, ECO:0000269|PubMed:15247478, ECO:0000269|PubMed:15641778, ECO:0000269|PubMed:16239244, ECO:0000269|PubMed:16608849, ECO:0000269|PubMed:20053667}.
Subcellular Location	Cytoplasm. Mitochondrion. Note=PubMed:18725397 reports localization exclusively in mitochondria.
Tissue Specificity	Expressed in the heart, peripheral blood lymphocytes and dermal fibroblasts. {ECO:0000269|PubMed:17468497}.
Top Pathways	Porphyrin and chlorophyll metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Frataxin CRISPR/Cas9 KO Plasmid (h) - sc-401628 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Frataxin HDR Plasmid (h) - sc-401628-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Frataxin Double Nickase Plasmid (h) - sc-401628-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Frataxin Double Nickase Plasmid (h2) - sc-401628-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Frataxin CRISPR Activation Plasmid (h) - sc-401628-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Frataxin CRISPR Activation Plasmid (h2) - sc-401628-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Frataxin Lentiviral Activation Particles (h) - sc-401628-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Frataxin Lentiviral Activation Particles (h2) - sc-401628-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Frataxin siRNA (h) - sc-40580 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Frataxin shRNA Plasmid (h) - sc-40580-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Frataxin shRNA (h) Lentiviral Particles - sc-40580-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Frataxin RNAi - H00002395-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Frataxin RNAi - H00002395-R06 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Frataxin RNAi - H00002395-R05 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU054361 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9008 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9008 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

FXN siRNA (Human) - CRH1651 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

FXN - MBS826881 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human FXN (NM_181425.2) - SHH297885 from Creative biogene Category siRNA Species Reactivities Human

Human FXN siRNA - orb262153 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

FXN shRNA Plasmid (Human) - CHH1651 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

FXN miRNA 3'UTR clone - MiUTR3H-08753 from Creative biogene Species Reactivities Human

FXN miRNA 3'UTR clone - MiUTR4H-TG03673 from Creative biogene Species Reactivities Human

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