FXN

Gene Symbol	FXN
Entrez Gene	2395
Alt Symbol	CyaY, FA, FARR, FRDA, X25
Species	Human
Gene Type	protein-coding
Description	frataxin
Other Description	Friedreich ataxia protein|frataxin, mitochondrial
Swissprots	Q15294 O15545 C9JJ89 Q5VZ01 A8MXJ6 O95656 Q16595
Accessions	AAA98508 AAA98509 AAB84047 AAD00734 AAD00735 AAD00736 AAD49778 CAA74077 EAW62473 EAW62474 Q16595 AA232366 AI951739 AK308620 BC023633 AAH23633 BC048097 AAH48097 BF058880 HQ447980 ADQ32463 U43747 AAA98510 NM_000144 NP_000135 NM_001161706 NP_001155178 NM_181425 NP_852090
Function	Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. Modulates the RNA-binding activity of ACO1. {ECO:0000269|PubMed:12785837, ECO:0000269|PubMed:15247478, ECO:0000269|PubMed:15641778, ECO:0000269|PubMed:16239244, ECO:0000269|PubMed:16608849, ECO:0000269|PubMed:20053667}.
Subcellular Location	Cytoplasm. Mitochondrion. Note=PubMed:18725397 reports localization exclusively in mitochondria.
Tissue Specificity	Expressed in the heart, peripheral blood lymphocytes and dermal fibroblasts. {ECO:0000269|PubMed:17468497}.
Top Pathways	Porphyrin and chlorophyll metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Frataxin ELISA Kit - ab115346 from Abcam Category ELISA Kit Sensitivity 0.3 ng/ml Range 107 %Sample specific recoverySample typeAverage %RangeCell culture supernatant10786% - 118%Serum10799% - 111%

Frataxin Human SimpleStep ELISATM Kit - ab176112 from Abcam Category ELISA Kit Prices $484.00 Sizes 1 x 96 tests Sensitivity 2.1 pg/ml Range 1.1 pg/ml - 800 pg/ml

Frataxin Profiling ELISA Kit - ab110173 from Abcam Category ELISA Kit Prices $464.00 Sizes 96 tests

Frataxin Protein Quantity Dipstick Assay Kit - ab109881 from Abcam Prices $354.00, $627.00 Sizes 30 tests, 90 tests

Mouse FXN / Frataxin ELISA Kit (Sandwich ELISA) - LS-F9813 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.055 ng/ml Range 0.156-10 ng/ml

Frataxin, mitochondrial (FXN), Human, ELISA Kit - CSB-EL009086HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

FXN (Human) IP-WB Antibody Pair - H00002395-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

FXN (Human) IP-WB Antibody Pair - H00002395-PW2 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

FXN (Human) Matched Antibody Pair - H00002395-AP21 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

FXN, ELISA Kit - MBS2515805 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of Human FXN is 14.063pg/mL (The sensitivity of this assay, or lowest detectable limit (LDL) was defined as the lowest protein concentration that could be differentiated from zero). Range 23.438-1500pg/mL

Frataxin ELISA KIT - DEIA7192 from Creative Diagnostics Category ELISA Kit

Human FXN(Frataxin) ELISA Kit - E-EL-H1634 from Elabscience Category ELISA Kit Sensitivity 14.06 pg/mL Range 23.44—1500 pg/mL

frataxin, ELISA Kit - MBS935917 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human FXN is typically less than 5.8 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 23.5 pg/ml -1500 pg/ml.

ELISA Kit for Frataxin (FXN) - SEC493Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.055ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Frataxin, mitochondrial(FXN) ELISA kit - CSB-EL009086HU from Cusabio Category ELISA Kit Sensitivity 5.8 pg/ml Range 23.5 pg/ml-1500 pg/ml

Human GRIN2A(Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2A) ELISA Kit - E-EL-H1634 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 14.06 pg/mLpg/mL Range 23.44~1500 pg/mL

Human FXN / Frataxin ELISA Kit (Sandwich ELISA) - LS-F23370 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 23.438 pg/ml Range 0.156-10 ng/ml

Frataxin, FXN, Human, ELISA Kit - E-EL-H1634 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 14.063 Range 23.438-1500pg/mL

Human Frataxin, mitochondrial (FXN) ELISA Kit - EKC33754 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 5.8 pg/ml Range 23.5 pg/ml-1500 pg/ml

Human FXN ELISA Kit - E015504 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human FXN is typically less than 5.8 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean

FXN ELISA Kit (Human) (OKCA01248) - OKCA01248 from Aviva Systems Biology Category ELISA Kit Prices $600.00 Sizes 96 wells Sensitivity 5.8 pg/mL Range 23.5 - 1,500 pg/mL

Human FXN (Frataxin) ELISA Kit - EKE60982 from Biomatik Category ELISA Kit Prices $609.00 Sizes 96 tests Sensitivity 14.06 pg/mL Range 23.44-1500 pg/mL

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